摘要
目的探讨外周血炎症因子白介素-6、肿瘤坏死因子-α、白介素-25水平在老年不明原因发热患者中的诊断价值。方法回顾性分析河南省人民医院呼吸内科2016年1月至2018年12月期间收治住院的老年不明原因发热患者200例,记录患者性别、热程及发病原因,分析患者的临床特点以及外周血白介素-6、肿瘤坏死因子-α、白介素-25表达水平。结果 200例患者中,确诊181例,确诊率为90.5%,死亡5例,病死率为2.5%。感染性疾病是最主要的病因,占总例数59.0%,其次为结缔组织疾病(占17.5%),第三是恶性肿瘤(占10.5%);不同发热病程的病因分布具有统计学意义(P<0.05)。IL-25在感染性疾病患者中表达显著高于其他组,IL-6在结缔组织病患者中表达明显升高,而TNF-α则在恶性肿瘤性疾病中的表达明显升高,差异均有统计学意义(P<0.05)。结论老年人不明原因发热患者病因主要为感染性疾病、结缔组织疾病和恶性肿瘤。外周血炎症因子白介素-6、肿瘤坏死因子-α、白介素-25水平的测定有助于老年人不明原因发热的病因诊断。
Objective To investigate the diagnosis value of inflammatory factors IL-6,TNF-α and IL-25 in elderly patients with fever of unknown origin.Methods Retrospective analysis of 200 cases of elderly patients with fever of unknown origin admitted from January, 2016 to December, 2018 in Department of Respiratory Medicine of Henan Province People’s Hospital, were analyzed retrospectively in the clinical features,and the level of expression of IL-6、TNF-α andIL-25, the gender, heat history and etiology were recorded. Results Of the 200 cases of FUO, 181 cases were diagnosed, the diagnosis rate was 90.5%, 5 cases died and the mortality was 2.5%. Infectious disease was the most important cause, accounting for 59.0% of the total cases, the second was connective tissue disease(17.5%), the third was malignant tumor(10.5%). The expression of IL-25 in peripheral blood of patients with infectious diseases was significantly higher than that of other groups,the expression of IL-6 in peripheral blood of patients with connective tissue disease was significantly higher than that of other groups, and the expression of TNF-α in peripheral blood of patients with malignant tumor was significantly higher than that of other groups(P <0.05). There were significant differences in the temporal distribution of cause(P <0.05). Conclusion The elderly of FUO patients’ main cause are infectious diseases, connective tissue diseases and malignant tumors. IL-6、TNF-α、IL-25 Of peripheral blood is helpful for the Diagnosis in elderly patients with FUO.
作者
雷小莉
王俊丽
LEI Xiao-li;WANG Jun-li(Department of Pulmonary and Critical Care Medicine,Henan Provincial People's Hospital,Zhengzhou 450003,China;不详)
出处
《医药论坛杂志》
2020年第4期23-25,共3页
Journal of Medical Forum
基金
河南省科技攻关计划资助项目(142102310418)。
