摘要
目的探讨肺癌分子标记物在病理诊断及临床治疗中意义的效果分析。方法方便选择自2017年5月-2018年5月收治的50例肺癌患者为对象,均具备齐全的临床资料;均实施肺癌分子标记物诊断,并探讨分析肺癌病理及临床治疗情况。结果免疫组化染色对象设定为异质性胞核核糖核蛋白,结果显示,癌细胞特异性为95.00%,癌细胞敏感性为83.00%;肿瘤内分泌的表型主要根据神经内分泌标记物进行确定和变化,比较常见的标记物包括嗜铬粒(N-CAM)以及神经细胞黏附分子(CD56)等,用于确诊小细胞癌的特异性标记物为CD56,而其中有90.00%的SCLC细胞膜被认定为强阳性;早期的临床标志物实验和监测中,根据单克隆抗体对肺癌进行诊断的结果显示,敏感性和特异性分别为92.00%和89.00%。经临床积极治疗后,50例肺癌患者中,有3例患者的病灶处于完全消失的状态,有9例患者部分病灶得到缓解,有21例趋于稳定,有17例存在明显进展,疾病治疗的总有效率为66.00%(33/50)。结论在病理诊断及临床治疗中实施肺癌分子标记物具有重要效果作用,可以给予临床治疗疾病提供有效、科学、积极的参考辅助作用,有重要作用价值。
Objective To investigate the effect of molecular markers of lung cancer on pathological diagnosis and clinical treatment.Methods A total of 50 patients with lung cancer who were treated from May 2017 to May 2018 were conveniently selected as subjects,all of whom had complete clinical data;they were diagnosed with molecular markers of lung cancer,and the pathology and clinical treatment of lung cancer were analyzed.Results The immunohistochemical staining object was set to heterogeneous nuclear ribonucleoprotein.The results showed that the cancer cell specificity was 95.00%and the cancer cell sensitivity was 83.00%.The tumor endocrine phenotype was mainly determined based on neuroendocrine markers and changes,the more common markers include chromaffin particles(N-CAM)and nerve cell adhesion molecules(CD56).The specific marker for the diagnosis of small cell cancer is CD56,and 90.00%of the SCLC cell membranes were identified as strong positive;in early clinical marker experiments and monitoring,the diagnosis of lung cancer based on monoclonal antibodies showed that the sensitivity and specificity were 92.00%and 89.00%,respectively.After active clinical treatment,3 out of 50 patients with lung cancer had completely disappeared,9 patients had partial remission,21 had stabilized,and 17 had significant progress.The total effective rate was 66.00%(33/50).Conclusion The implementation of molecular markers for lung cancer in pathological diagnosis and clinical treatment has important effects.It can provide effective,scientific and positive reference auxiliary effects for clinical treatment of diseases,and has important role value.
作者
邹莉娜
ZOU Li-na(Department of Pathology,Laiyang Traditional Chinese Medicine Hospital,Laiyang,Shandong Province,265200 China)
出处
《中外医疗》
2020年第12期19-21,共3页
China & Foreign Medical Treatment
关键词
肺癌分子标记物
病理诊断
临床治疗
意义
效果
Molecular markers of lung cancer
Pathological diagnosis
Clinical treatment
Significance
Effect
