摘要
白藜芦醇是一种非黄酮类多酚化合物,具有抗炎、抗氧化、抗衰老、调节免疫等多种生物学活性,被广泛应用于多种疾病的研究。白藜芦醇能促进成骨细胞的分化和矿化,并能抑制破骨细胞的形成和骨吸收功能。白藜芦醇对炎症、香烟烟雾、颗粒诱导及雌激素缺乏等造成的骨损伤具有保护作用,但不同剂量的白藜芦醇对化疗状态下的骨损伤可能有不同的影响。本研究主要综述白藜芦醇对多种不同条件下骨及骨组织细胞的影响及作用机制,为白藜芦醇作为临床治疗相关疾病药物的安全性及有效性提供依据。
Resveratrol is a non-flavonoid polyphenol compound, possessing many biological activities such as anti-inflammatory, anti-oxidation, anti-aging, immune regulation and so on. It is widely used in the study of many diseases. Resveratrol can promote the differentiation and mineralization of osteoblasts, inhibit the formation of osteoclasts and bone resorption. Resveratrol has protective effects on bone in the state of inflammation,cigarette smoke, particle induction and estrogen deficiency, but different doses of resveratrol have different effects on bone in the state of chemotherapy. The effects and mechanism of resveratrol on bone and bone tissue cells under different conditions were summarized, which provided a basis for the safety and effectiveness of resveratrol as a drug for clinical treatment of related diseases.
作者
张倩
韩婕
汤旭磊
Zhang Qian;Han Jie;Tang Xu-lei(Department of Endocrinology,The First Hospital of Lanzhou University,Lanzhou 730000,China)
出处
《兰州大学学报（医学版）》
CAS
2020年第3期23-27,共5页
Journal of Lanzhou University（Medical Sciences）
基金
甘肃省科技计划项目(144FKCA075)。
