摘要
目的探讨外周血中性粒细胞-淋巴细胞比值(NLR)、血小板-淋巴细胞比值(PLR)及血小板参数在宫颈癌诊断中的应用价值。方法选取广东省妇幼保健院2018年1月至2019年8月收治的宫颈癌患者130例(宫颈癌组),癌前病变患者127例(癌前病变组)与同期130例健康体检女性(对照组)为研究对象。比较3组NLR、PLR、血小板计数(PLT)、血小板分布宽度(PDW)、血小板比容(PCT)、平均血小板体积(MPV)、大血小板比例(PLCR)水平,同时采用受试者工作特征曲线(ROC曲线)分析各指标的诊断效能。结果3组PDW水平比较,差异无统计学意义(P>0.05);与对照组比较,癌前病变组和宫颈癌组MPV、PLCR水平均明显降低(P<0.05),NLR水平明显升高(P<0.05);与对照组、癌前病变组比较,宫颈癌组PLT、PCT及PLR水平均明显升高(P<0.05)。ROC曲线分析结果显示,各指标诊断宫颈癌的曲线下面积从高到低依次为PLT(0.689)、NLR(0.672)、MPV(0.669)、PLCR(0.658)、PLR(0.645)和PCT(0.632);PLT的诊断灵敏度为67.69%,特异度为66.92%;NLR的诊断灵敏度为44.62%,特异度为86.15%。结论MPV、PLCR、NLR、PLT、PCT及PLR对宫颈癌具有一定的诊断价值。
Objective To explore the application value of peripheral blood neutrophil-lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR)and platelet parameters in the diagnosis of cervical cancer.Methods A total of 130 cases of cervical cancer(cervical cancer group),127 cases of precancerous lesions(precancerous lesion group)treated in Guangdong Maternal and Child Health Hospital and 130 healthy women(control group)underwent physical examination in the same period were selected as the study objects.The levels of NLR,PLR,platelet count(PLT),platelet distribution width(PDW),plateletcrit(PCT),mean platelet volume(MPV)and platelet larger cell ratio(PLCR)in the 3 groups were compared,and the receiver operating characteristic curve(ROC curve)was used to analyze the diagnostic efficacy of each index.Results There was no significant difference in PDW levels among the 3 groups(P>0.05).Compared with the control group,the levels of MPV and PLCR in the precancerous lesion group and cervical cancer group were significantly decreased(P<0.05),and the level of NLR was significantly increased(P<0.05).Compared with the control group and the precancerous lesion group,the levels of PLT,PCT and PLR in the cervical cancer group were significantly increased(P<0.05).ROC curve analysis results show that the area under the curve for the diagnosis of cervical cancer from high to low was PLT(0.689),NLR(0.672),MPV(0.669),PLCR(0.658),PLR(0.645)and PCT(0.632).The diagnostic sensitivity of PLT was 67.69%,and the specificity was 66.92%;the diagnostic sensitivity of NLR was 44.62%,and the specificity was 86.15%.Conclusion MPV,PLCR,NLR,PLT,PCT and PLR have certain diagnostic value for cervical cancer.
作者
叶金锋
何宇婷
吴立红
张姗姗
穆小萍
YE Jinfeng;HE Yuting;WU Lihong;ZHANG Shanshan;MU Xiaoping(Department of Clinical Laboratory,Guangdong Maternal and Child Health Hospital,Guangzhou,Guangdong 510000,China;Department of Clinical Laboratory,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510080,China;Department of Pathology, Guangdong Maternal and Child Health Hospital,Guangzhou,Guangdong 510000,China)
出处
《国际检验医学杂志》
CAS
2020年第12期1445-1447,1452,共4页
International Journal of Laboratory Medicine
基金
广东省自然科学基金项目(2018A030313982)。
