摘要
目的:探讨复方苦参注射液联合化疗对结直肠癌术后患者免疫功能改善的影响。方法:将我院收治的136例大肠癌术后患者随机分为对照组和观察组各68例,对照组使用Xelox化疗方案治疗,观察组在对照组的基础上联合应用复方苦参注射液,比较两组患者的术后营养状况,观察多种免疫功能指标T淋巴细胞亚群、补体C3、C4等水平变化,监测血清中表皮生长因子(EGF)、胰岛素样生长因子1(IGF-1)、白细胞介素-17(IL-17)水平;通过EORTC制定的QLQ-C30调查表评价两组患者术后的生活质量。结果:两组患者在术后1天的营养指标、免疫功能及生活质量无显著差异(P>0.05);术后7天,观察组患者血清中大部分营养指标水平明显高于术后1天及对照组患者(P<0.05);免疫功能血清指标CD4^+、CD4^+/CD8^+、IgG等水平与对照组相比明显增加;血清EGF、IGF-1、IL-17水平较对照组显著降低(P<0.05);观察组患者的生活质量评分显著高于对照组(P<0.05)。结论:复方苦参注射液联合化疗利于改善患者的营养状况,增强CRC术后患者的机体免疫水平,显著提高患者的生存质量,其起效机制可能在于通过抑制血清中EGF、IGF-1、IL-17水平而抑制肿瘤生长。
Objective To investigate the Influence of nutritional status,immune function,inflammatory factor level and quality of life improvement for treating postoperative patients with colorectal cancer with compound bitter ginseng injection,apatinib combined with chemotherapy.Methods 136 patients were randomly divided into a control group of 68 cases and an observation group of 68cases.Patients in the control group were treated with apatinib combined with chemotherapy;while patients in the observation group were treated with compound bitter ginseng injection on the basis of control group.The research was aimed at evaluating the effectiveness by comparing postoperative nutritional status and the levels of immune function index T lymphocyte subsets,immunoglobulin,complement C3 and C4,monitoring the levels of serum EGF,IGF-1 and IL-17,and evaluating the quality of life of patients with the life quality questionnaire developed by EORTC.Results There was no significant difference between the nutritional indicators,immunological function,inflammatory factor level and quality of life of 1d patients after surgery(P>0.05);After postoperative 7 days,the levels of RBC,Hb,PA,TRF and Alb in the serum of the observation group were significantly higher than those in 1 day and control group(P<0.05).The serum immunological function index,such asCD4+,CD4+/CD8+,IgG,C3 and C4 were significantly higher than the control group,while CD8+level significantly decreased(P<0.05).Levels of serum EGF,IGF-1 and IL-17 were significantly lower than those in the control group(P<0.05).The cognitive function,physical function,emotional function,role function and social function score of the observation group were significantly higher than those in the control group(P<0.05).Conclusion The therapy is good to improve the nutritional status of the patients,enhance the postoperative immune function in patients with CRC,and significantly improve the patient's quality of life,its effect mechanism may be that inhibit serum EGF,IGF 1 and IL-17 levels to inhibit tumor growth.
作者
尹宏
赖思帧
张春泽
张庆怀
YIN Hong;LAI Si-zhen;ZHANG Chun-ze(Department of Anus&Intestine Surgery,Tianjin People's Hospital,Tianjin(300121),China)
出处
《中国中西医结合外科杂志》
CAS
2020年第3期457-464,共8页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
国家自然科学基金面上项目(81872236)
天津市科技支撑重点研发计划项目(19YFZCSY00420)。
关键词
结直肠癌
复方苦参注射液
阿帕替尼
化疗
Colorectal cancer
compound sophora injection
apatinib
chemotherapy
