摘要
目的探讨血清人附睾蛋白(HE4)、血清可溶性间皮素相关蛋白(SMRP)、白细胞介素-8(IL-8)、白细胞介素-17(IL-17)联合检测在上皮性卵巢癌患者中的意义及其临床应用分析。方法选取2013年8月至2018年8月海南省妇女儿童医学中心诊治的卵巢癌患者(n=150)和卵巢良性肿瘤患者(n=150)作为研究对象。另外再选取150例海南省妇女儿童医学中心体检的健康女性为对照组。结果卵巢癌组血清中HE4、SMRP、IL-8、IL-17水平显著高于卵巢良性肿瘤组和对照组(P<0.05),卵巢良性肿瘤组血清中HE4、SMRP、IL-8、IL-17水平与对照组无显著差异(P>0.05);卵巢癌组单项检测和联合检测血清中HE4、SMRP、IL-8、IL-17诊断卵巢癌的阳性率显著高于卵巢良性肿瘤组和对照组(P<0.05),卵巢良性肿瘤组单项检测的阳性率与对照组无显著差异(P>0.05),卵巢良性肿瘤组联合检测的阳性率显著高于对照组(P<0.05),卵巢癌组各单项检测的阳性率均显著低于联合检测的阳性率(P<0.05);联合检测的灵敏度、准确性和特异度显著高于各单项检测(P<0.05)。结论血清中HE4、SMRP、IL-8、IL-17联合检测能够有效鉴别卵巢癌,显著提高诊断率,对于卵巢癌患者的早期诊断具有重要意义,值得进一步推广应用。
Objective To investigate the clinical significance and application of combined detection of serum human epididymal protein(HE4),serum soluble mesothelin-related protein(SMRP),interleukin-8(IL-8),and interleukin-17(IL-17)levels in patients with ovarian cancer.Methods 150 patients with ovarian cancer and 150 patients with benign ovarian tumor diagnosed and treated in Hainan Maternal and Child Health Hospital from August 2013 to August 2018 were selected.Another 150 healthy women undergoing physical examination in Hainan Maternal and Child Health Hospital were selected as the control group.Results The serum levels of HE4,SMRP,IL-8,and IL-17 in the ovarian cancer group were significantly higher than those in the benign ovarian tumor group and the control group(P<0.05),and there was no significant difference between the benign ovarian tumor group and the control group(P>0.05).The positive diagnosis rate of ovarian cancer in the single and combined detection of serum HE4,SMRP,IL-8,and IL-17 levels in the ovarian cancer group was significantly higher than that in the benign ovarian tumor group and the control group(P<0.05);there was no statistically significant difference in the positive diagnosis rate in the single detection between the benign ovarian tumor group and the control group(P>0.05);the positive diagnosis rate in the combined detection of the benign ovarian tumor group was higher than that in the control group(P<0.05).The positive diagnosis rate of each single detection in the ovarian cancer group was significantly lower than that of the combined detection(P<0.05);the sensitivity,accuracy and specificity of the combined detection was significantly higher than that of the single detection(P<0.05).Conclusions The combined detection of serum HE4,SMRP,IL-8,and IL-17 levels can effectively identify ovarian cancer and significantly improve the diagnosis rate,which is of great significance for the early diagnosis of ovarian cancer and deserves further promotion and application.
作者
胡传翠
李波
聂明朝
HU Chuancui;LI Bo;NIE Mingzhao(Inspection Center,Maternal and Child Health Hospital of Hainan Province,Haikou 571100,Hainan,China;Department of Gynecology,Maternal and Child Health Hospital of Hainan Province,Haikou 571100,Hainan,China)
出处
《中国性科学》
2020年第5期25-29,共5页
Chinese Journal of Human Sexuality
基金
海南省自然科学基金项目(20158313)。
关键词
人附睾蛋白
血清可溶性间皮素相关蛋白
白细胞介素-8
白细胞介素-17
联合检测
卵巢癌
Human epididymal protein(HE4)
Serum soluble mesothelin-related protein(SMRP)
Interleukin-8(IL-8)
Interleukin-17(IL-17)
Combined detection
Ovarian cancer
