摘要
目的调查住院男性2型糖尿病患者血清25-羟维生素D[25(OH)D]水平,并探讨其与性激素之间的关系。方法选择住院男性2型糖尿病患者371例,检测其25(OH)D水平、糖脂代谢指标、骨代谢指标和性激素指标。根据25(OH)D水平采用四分法将患者分为四组,比较组间糖脂代谢及性激素指标的差异。采用多元线性回归法分析25(OH)D与总睾酮及其他指标间的相关性。结果维生素D缺乏或不足患者占住院男性2型糖尿病人群的96.5%。25(OH)D较高的患者有较高的高密度脂蛋白胆固醇(HDL-C),而体重指数(BMI)、稳态模型评估的胰岛素抵抗指数(HOMA-IR)和三酰甘油(TG)则相对较低(P<0.05)。在线性回归模型中,25(OH)D与总睾酮(TT)呈线性正相关关系(β=0.116,P=0.006),在校正BMI后上述相关性消失(β=0.061,P=0.053)。结论在住院男性2型糖尿病患者中,维生素D呈普遍缺乏或不足的状态,维生素D与总睾酮之间呈线性正相关,但受BMI影响。
Objective To investigate the serum level of 25-hydroxy vitamin D[25(OH)D]in hospitalized type 2 diabetes men and determine the association between 25(OH)D and sex hormones.Methods We performed a study among 371 male adults with type 2 diabetes in hospital.The fasting blood was collected for the measurements of 25(OH)D,glucose and lipid metabolism indexes,bone metabolism indexes and sex hormones.Patients were divided into four groups according to the quartiles of 25(OH)D.The differences of glycolipid metabolism and sex hormone indexes between groups were compared.Multivariate linear regression method was used to analyze the correlations between 25(OH)D,glucose and sex hormones.Results Patients with vitamin D deficiency or insufficiency accounted for 96.5%of the hospitalized type 2 diabetes men.Patients with higher 25(OH)D were with higher HDL-C and lower BMI,HOMA-IR,and TG(P<0.05).In the linear regression model,25(OH)D had a significant correlation with TT(β=0.116,P=0.006),and 25(OH)D had no statistically significant association with TT(β=0.061,P=0.053)after adjusting for BMI.Conclusion In hospitalized male patients with type 2 diabetes,vitamin D is generally deficient or insufficient,and there is a positive linear correlation between 25(OH)D and testosterone,however,it is affected by BMI.
作者
龚彤
韩雪
陈国芳
刘超
Gong Tong;Han Xue;Chen Guofang;Liu Chao(Endocrinology Department,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing 210028,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2020年第5期400-404,共5页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金(81800756)
江苏省六大人才高峰(WSN-035)。
关键词
糖尿病
2型
男性
25羟维生素D
糖脂代谢
性激素
Diabetes mellitus
type 2
Males
25(OH)D
Glucose and lipid metabolism
Sex hormones
