摘要
目的探讨桑夏扶正汤剂联合雾化治疗小儿病毒性肺炎的临床效果及安全性。方法选取2018年1月—2019年1月治疗的病毒性肺炎患儿150例,按照治疗方法分为联用组与西药组。联用组给予桑夏扶正汤剂联合雾化治疗,西药组给予奥司他韦联合利巴韦林治疗。比较2组治疗前后血清降钙素原(PCT)、C反应蛋白(CRP)水平;观察2组治疗后肺炎严重度评分(PSI)等级、临床症状消失时间、血氧饱和度、呼吸频率以及总不良反应发生率。结果与治疗前比较,治疗后各时间段2组的血清PCT和CRP水平明显降低(P<0.05)。治疗后2、7、14 d,联用组血清PCT和CRP水平明显低于西药组(P<0.05)。治疗后,联用组血氧饱和度、呼吸频率、PSI评分等级、临床症状消失时间及总不良反应发生率明显优于西药组(P<0.05)。结论桑夏扶正汤剂联合雾化治疗小儿病毒性肺炎,可以在祛除病邪的同时,兼顾调整机体阴阳、免疫平衡,有效减轻病毒性肺炎的炎症反应,提高患儿疗效,且不良反应发生率少,安全性高。
Objective To explore the clinical effect and safety of Sangxia Fuzheng decoction combined with atomization in the treatment of viral pneumonia in children.Methods From January 2018 to January 2019,150 children with viral pneumonia were selected and divided into two groups according to the treatment method:combination group and western medicine group.The combination group was given Sangxia Fuzheng decoction combined with atomization treatment,while the western medicine group was given Oseltamivir combined with Ribavirin treatment.Before and after treatment,the levels of serum procalcitonin(PCT)and C-reactive protein(CRP)were compared.The pneumonia severity index(PSI),the disappearance time of clinical symptoms,blood oxygen saturation,respiratory rate and the total incidence of adverse reactions were observed.Results Compared with those before treatment,the levels of serum PCT and CRP in the two groups at different time periods were significantly lower after treatment(P<0.05).At 2,7 and 14 days after treatment,the levels of serum PCT and CRP in the combination group were significantly lower than those in the western medicine group(P<0.05).After treatment,blood oxygen saturation,respiratory rate,PSI score,disappearance time of clinical symptoms and total incidence of adverse reactions in the combination group were significantly better than those in the western medicine group(P<0.05).Conclusion The combination of Sangxia Fuzheng decoction and atomization in the treatment of viral pneumonia in children can not only eliminate pathogenic factors,but also adjust the balance of Yin and Yang and immunity.In addition,it can effectively reduce the inflammatory reaction of viral pneumonia,and improve the curative effect on children,with lower incidence of adverse effects and better safety.
作者
刘媛
范中娥
范方勇
范中欣
马国妹
郑丽
代树栋
LIU Yuan;FAN Zhong-e;FAN Fang-yong;FAN Zhong-xin;MA Guo-mei;ZHENG Li;DAI Shu-dong(Department of Pediatrics,Huanghua people's Hospital,Huanghua,Hebei 061100,China;Department of Obstetrics and Gynecology,Huanghua Maternal and Child Health and Family Planning Service Center,Huanghua,Hebei 061100,China;Department of Otolaryngology,Boai Hospital,Huanghua Development Zone,Huanghua,Hebei 061100,China)
出处
《解放军医药杂志》
CAS
2020年第6期56-59,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
河北省中医药管理局科研计划项目(2019311)。
关键词
肺炎
病毒性
雾化
桑夏扶正汤剂
儿童
C反应蛋白
降钙素原
Pneumonia
viral
Atomization
Sangxia fuzheng decoction
Child
C-reactive protein
Procalcitonin
