摘要
体外循环(CPB)是心血管疾病心内直视手术中的必要技术,心肌缺血再灌注损伤(MIRI)是术后心功能障碍的主要原因之一。近年来,研究发现脂联素受体1结合蛋白(APPL1)不仅可以通过调节心肌的糖脂代谢、增加胰岛素敏感性、改善胰岛素抵抗来减轻MIRI,而且可以通过增加抗心肌细胞凋亡发挥减轻MIRI的保护作用。现就APPL1在MIRI的作用及其机制作一综述,为临床防治MIRI寻求新的靶点提供思路。
Cardiopulmonary bypass(CPB)is an essential technique in heart surgery for cardiovascular disease.Myocardial ischemia-reperfusion injury(MIRI)is the main cause of cardiac dysfunction after such surgery.In recent years,it has been found that adiponectin receptor 1 binding protein(APPL1)could reduce MIRI and protect the myocardium for MIRI by not only regulating myocardial glucose and lipid metabolism,increasing insulin sensitivity and alleviating insulin resistance and MIRI,but also increasing anticardiomyocyte apoptosis.Therefore,this article reviewed the role of APPL1 in myocardial ischemia-reperfusion injury and its potential mechanisms,and provided ideas for seeking new targets for clinical prevention or treatment of MIRI.
作者
赵林
梁贵友
Zhao Lin;Liang Guiyou(Department of Cardiovascular Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou 563099,China;Guizhou Medical University,Guiyang Guizhou 550025,China)
出处
《遵义医科大学学报》
2020年第2期259-263,共5页
Journal of Zunyi Medical University
基金
国家自然科学基金资助项目(NO:81360035,NO:81560058,NO:81960051)
贵州省社发攻关项目(NO:黔科合SZ字[2014]3022)。
关键词
脂联素受体1结合蛋白
心肌缺血再灌注损伤
脂联素
adiponectin receptor 1 binding protein
myocardial ischemia-reperfusion injury
adiponectin
