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同步放化疗治疗老年中晚期宫颈癌的效果及对血清CA125、SCCA表达的影响 被引量:4

Effect of Concurrent Chemoradiotherapy on Elderly Patients with Advanced Cervical Cancer and Its Effect on Serum CA125 and SCCA Expression
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摘要 目的:探讨同步放化疗治疗老年中晚期宫颈癌的效果及对血清糖链抗原125(CA125)与鳞状细胞癌相关抗原(SCCA)表达的影响.方法:选取本院2015年6月-2016年7月收治的77例老年中晚期宫颈癌患者,采用随机数字表法分为观察组(n=34)与对照组(n=33).对照组给予单纯放疗治疗,观察组给予同步放化疗治疗.比较两组疗效、不良反应发生情况、血清CA125、SCCA表达量及各时间点生存率.结果:观察组治疗有效率与疾病控制率均高于对照组(P<0.05).观察组骨髓抑制与胃肠道反应发生率高于对照组(P<0.05).治疗后,观察组血清CA125与SCCA表达量均低于对照组(P<0.05).观察组2、3年生存率均高于对照组(P<0.05).结论:同步放化疗治疗老年中晚期宫颈癌的效果确切,可下调血清CA125、SCCA表达,延长患者生存期,值得推广应用. Objective:To investigate the effect of concurrent chemoradiotherapy on elderly patients with advanced cervical cancer and its effect on serum carbohydrate antigen 125(CA125),squamous cell carcinoma antigen(SCCA)expression.Method:A total of 77 elderly patients with advanced cervical cancer admitted to our hospital from June 2015 to July 2016 were selected.According to the random number table method,they were divided into observation group(n=34)and control group(n=33).The control group was treated with radiotherapy alone,and the observation group was treated with concurrent chemoradiotherapy.The efficacy,adverse reactions,serum CA125 and SCCA expression levels and survival rates at each time point were compared between the two groups.Result:The treatment response rate and disease control rate of the observation group were higher than those of the control group(P<0.05).The incidence of myelosuppression and gastrointestinal reactions in the observation group were higher than those in the control group(P<0.05).After treatment,the expression levels of serum CA125 and SCCA in the observation group were lower than those in the control group(P<0.05).The 2 and 3 years survival rates of the observation group were higher than those in the control group(P<0.05).Conclusion:Concurrent chemoradiotherapy has a definite effect on the treatment of advanced cervical cancer in the elderly.It can reduce the expression of serum CA125 and SCCA,and prolong the survival of patients,which is worthy of promotion and application.
作者 陈晓明 CHEN Xiaoming(Jiamusi Cancer and Tuberculosis Hospital,Jiamusi 154007,China)
出处 《中国医学创新》 CAS 2020年第16期107-110,共4页 Medical Innovation of China
关键词 同步放化疗 中晚期宫颈癌 CA125 SCCA Concurrent chemoradiotherapy Advanced cervical cancer CA125 SCCA
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  • 1朱朝勇,李志燕,郭生梅,吴德慧,王烈宏.FP与TP方案在早期高危宫颈癌术后同步放化疗中的有效性和安全性的临床研究[J].青海医药杂志,2012,42(4):5-7. 被引量:6
  • 2刘馨,白艳香.血清肿瘤标志物和宫颈癌分期的相关性及其机制[J].中国老年学杂志,2014,34(11):2945-2946. 被引量:10
  • 3陈涛利,卞翠翠,杨雷,刘子玲.早期高危宫颈癌患者术后不同治疗方案的临床疗效[J].中国老年学杂志,2015,35(1):55-57. 被引量:25
  • 4刘国燕,许倩,郜智慧.PCF方案化疗与放射治疗同步进行治疗Ⅱ/Ⅲ期宫颈癌[J].中国癌症杂志,2007,17(4):333-335. 被引量:9
  • 5Kidd EA, Siegel BA, Dehdashti F, et al. Clinical outcomes of defini- tive intensity - modulated radiation therapy with fluorodeoxyglucose - positron emission tomography simulation in patients with locally ad- vanced cervical cancer [ J]. Int J Radiat Oncol Biol Phys, 2010, 77 (4) :1085 -1091.
  • 6Osman M. The role of neoadjuvant chemotherapy in the management of locally advanced cervix cancer: a systematic review[J]. Oncol Rev, 2014, 8(2): 250.
  • 7Li Y, Wang X, Li J, et al. Combination therapy of liposomal paclitaxel and cisplatin as neoadjuvant chemotherapy in locally advanced cervical cancer[J]. Eur J Oynaecol Oncol, 2015, 36(1): 54-58.
  • 8Liu YG, Zhang XL, Liu FM. The mechanism and inhibitory effect of recombinant human P53 adenovims injection combined withpaclitaxel on human cervical cancer cell HeLa [J]. Eur Rev Med Pharmacol Sci, 2015, 19(6): 1037-1042.
  • 9Dang YP, Yuan XY, Tian R, et al. Curcumin improves the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cells via the NF-~B-p53-caspase-3 pathway [J]. Exp Ther Med, 201fi, 9(4): 1470-1476.
  • 10Scandurra G, Scibilia G, Banna GL, et al. Efficacy and tolerability of paclitaxel, ifosfamide, and cisplatin as a neoadjuvant chemotherapy in locally advanced cervical carcinoma [J]. J Gynecol Oncol, 2015, 26 (2): 118-124.

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