摘要
目的:探究γ-干扰素释放试验联合血清高迁移率族蛋白B1(high mobility group box 1,HMGB1)及Fe测定对活动性结核病患者的诊断效能。方法:选取2018年1-12月于本院就诊的活动性肺结核患者作为活动组(n=154),潜伏性结核分枝杆菌感染者作为潜伏组(n=158)。比较两组γ-干扰素、HMGB1及Fe水平。比较血清γ-干扰素释放试验、HMGB1及Fe单独及联合检测对活动性结核的诊断效能。结果:活动组γ-干扰素水平明显高于潜伏组(P<0.05)。活动组HMGB1水平高于潜伏组,Fe水平低于潜伏组(P<0.05)。γ-干扰素释放试验的最佳截断值为2.72 IU/mL;血清HMGB1检测的最佳截断值为4.48μg/L;血清Fe检测的最佳截断值为10.3μmol/L。联合诊断的曲线下面积明显高于各项单独检测,且联合诊断的准确度明显高于各项单独检测(P<0.05)。结论:血清γ-干扰素释放试验联合HMGB1及Fe测定可提高活动性结核的诊断准确度,同时保持较好的敏感度,对活动性结核诊断有重要的临床价值。
Objective:To explore the diagnostic value ofγ-interferon release test combined with serum high mobility group box 1(HMGB1)and Fe determination in patients with active tuberculosis.Method:Active pulmonary tuberculosis patients admitted to our hospital from January to December 2018 were selected as the active group(n=154),and those infected with latent mycobacterium tuberculosis were selected as the latent group(n=158).The levels ofγ-interferon,HMGB1 and Fe between the two groups were compared.The diagnostic value of serumγ-interferon release test,HMGB1 and Fe single and combined detection for active tuberculosis were compared.Result:The level ofγ-interferon in the active group was significantly higher than that in the latent group(P<0.05).The level of HMGB1 in the active group was higher than that in the latent group,the level of Fe was lower than that in the latent group(P<0.05).The best cut off value ofγ-interferon release test was 2.72 IU/mL.The best cut off value of serum HMGB1 detection was 4.48μg/L,and the best cutoff value of serum Fe detection was 10.3μmol/L.The area under the curve of combined diagnosis was significantly higher than that of individual detection,and the accuracy of combined diagnosis was significantly higher than that of individual detection(P<0.05).Conclusion:Serumγ-interferon release test combined with HMGB1 and Fe determination can improve the diagnostic accuracy of active tuberculosis and maintain good sensitivity at the same time,which has important clinical value for active tuberculosis diagnosis.
作者
李玉美
陈胤文
余晓琳
洪建明
林炳耀
曾今诚
林东子
LI Yumei;CHEN Yinwen;YU Xiaolin;HONG Jianming;LINBingyao;ZENG Jincheng;LIN Dongzi(The Sixth People’s Hospital of Dongguan City,Dongguan 523008,China;不详)
出处
《中国医学创新》
CAS
2020年第17期119-122,共4页
Medical Innovation of China
基金
广东省医学科学技术研究基金项目(B2018014)
东莞市社会科技发展(重点/一般)项目(2018507150051657)。
