摘要
目的了解我院药品不良反应(ADR)发生的规律和特点,为临床合理用药提供参考。方法收集广州市第一人民医院南沙医院2015年1月1日—2019年12月31日上报国家药品不良反应监测中心的224例ADR,统计分析发生ADR的患者性别、年龄、药品种类、剂型、给药途径、累及系统等情况。结果224例ADR报告中,女性报告数(51.79%)高于男性(48.21%),50岁以上的病人报告数占48.6%,其中60岁以上属于高发年龄段(30.8%);抗感染药ADR报告数最多(43.3%),其次是心血管系统用药(12.95%),第三是中枢神经系统用药(12.50%);静脉给药ADR报告数最多(57.14%),其次是口服给药(40.18%),剂型因素中,最高为注射液(32.59%),其次为普通片剂(28.57%),第三位粉针剂(24.55%);ADR累及系统中,皮肤及附件损害最多(26.43%),其次是胃肠系统损害(20.70%)和中枢及外周神经系统损害(18.06%);上报来源以药师上报为主(72.77%),护士上报率为0。结论临床应加强合理用药,尤其抗菌药物使用,减少静脉给药途径,重点关注50岁以上ADR高发人群,加强ADR监测医护宣教,提高ADR上报率和报告质量。
Objective To investigate the occurrence and distribution of adverse drug reaction ADR from 2015 to 2019 in our hospital and provide relevant information for clinical rational usage of medication.Methods 224 ADR reported to National Center were collected from Nansha hospital of Guangzhou First People's Hospital monitoring during 2015~2019.Those ADR were analyzed in terms of gender and age of patients,type of drugs,route of administration,dosage form,etc.Results Among 224 ADR reports,the occurrence rate of ADR in female(51.79%)was higher than male,patients over the age of 50 accounted for 48.6%and age over 60 were at high risk of ADR.The top three of medicine were anti-infectious agent(43.3%),cardiovascular medicine(12.95%)and central nervous system medication(12.50%).Intravenous administration and oral medication accounted for 57.14%,40.18%respectively.For the dosage form factor,the top three were injection(32.59%),ordinary tablet(28.57%)and powder-injection(24.55%).Major systems involved in ADR were lesion of skin and its appendages(26.43%),gastrointestinal system(20.70%),central and peripheral nervous systems(18.06%).Sources of ADR were mainly composed of pharmacist(72.77%)and the nurse reported 0.Conclusion Clinical rational drug use should be strengthen especially antibacterial agents.The intravenous route should be decreased.Patients over the age of 50 deserved special attention.It is necessary to enhance awareness and education of medical workers to improve the reported rate and quality of ADR.
作者
付腾飞
严懿
郑珊婉
FU Tengfei;YAN Yi;ZHENG Shanwan(Department of Pharmacy,Guangzhou First People's Hospital,The Second Affiliated Hospital of South China University of Technology,Guangzhou 510180,China;Department of Pathology,Guangzhou First People's Hospital,The Second Affiliated Hospital of South China University of Technology,Guangzhou 510180,China)
出处
《广州医药》
2020年第3期93-97,101,共6页
Guangzhou Medical Journal
关键词
药品不良反应
分析
合理用药
Adverse drug reaction
Analysis
Rational medication
