摘要
目的观察并分析双环醇联合还原型谷胱甘肽治疗抗结核药物性肝炎患者的临床疗效。方法收集本院2016年1月至2019年1月收治抗结核药物性肝炎患者80例,作为本研究对象。参照随机抽样方法,将所选80患者随机分为观察组和对照组,各组40例。对照组:采用还原型谷胱甘肽进行药物治疗;观察组:对照组药物治疗基础上,增加口服双环醇。观察并分析两种治疗方案治疗效果、肝功能改善情况、SOD水平、MDA水平、GSH-PX水平、以及不良反应情况。结果①观察组与对照组治疗总体有效率分别为97.50%、82.50%。两组患者治疗总有效率进行对比,观察组明显比对照组高且差异明显,具备统计学意义(P<0.05);②两组患者治疗后,观察组患者肝功能指标ALT(36.5±0.3)U/L、AST(31.7±0.6)U/L、TBIL(13.5±0.3)μmol/L明显比对照组低,差异明显具有统计学意义(P<0.05);③观察组患者SOD、GSH-PX、MDA水平明显优于对照组,差异具有统计学意义(P<0.05);④观察组不良反应率为7.50%,对照组不良反应率为10.00%,两组患者不良反应率相似,差异无统计学意义(P>0.05)。结论双环醇联合还原型谷胱甘肽治疗抗结核药物性肝炎患者的临床疗效佳,可有效保护患者肝功能,值得临床广泛借鉴。
Objective To observe and analyze the clinical effi cacy of bicyclic alcohol combined with reduced glutathione in treating patients with tuberculous hepatitis.Methods 80 cases of antituberculous hepatitis patients from January 2016 to January 2019 were collected as the subjects of this study.With reference to the random sampling method,the 80 patients were randomly divided into observation group and control group,with 40 cases in each group.Control group:Glutathione was treated with drug reduction;Observation group:control group based on drug treatment,increased oral dicyclic alcohol.To observe and analyze the treatment effect of two treatment schemes,improvement of liver function,SOD level,MDA level,GSH-PX level,and adverse reactions.Results(1)The total effective rate of treatment in the observation group and the control group was:97.50%and 82.50%.The total effective rate of treatment was compared between the two groups.The observation group was signifi cantly higher than the control group and had statistical signifi cance(P<0.05).(2)After treatment of the two groups of patients,the liver function indicators of ALT(36.5±0.3)U/L,AST(31.7±0.6)U/L,TBIL(13.5±0.3)μmol/L in the observation group were signifi cantly lower than in the control group.The difference was statistically signifi cant(P<0.05);(3)The level of SOD,GSH-PX and MDA in the observation group was superior to that of the control group,and the difference was statistically signifi cant(P<0.05).(4)The ADR was 7.50%in the observation group and 10.00%in the control group.The ADR rate was similar in the two groups,and the difference was not statistically signifi cant(P>0.05).Conclusion Bicyclic alcohol combined with reduced glutathione is effective in treating patients with tuberculous hepatitis.It can effectively protect liver function and is worthy of extensive clinical study and reference.
作者
于雪
丁宁
YU xue;DING Ning(Shenyang Sixth People's Hospital,Shenyang 110006,China)
出处
《中国医药指南》
2020年第18期104-105,共2页
Guide of China Medicine
关键词
双环醇
还原型谷胱甘肽
抗结核药物性肝炎
临床疗效
肝功能改善
Bicyclol
Reduced glutathione
Anti-tuberculosis drug hepatitis
Clinical effi cacy
Improved liver function
