摘要
目的探究聚乙烯醇载药微球介入栓塞治疗原发性肝癌的有效性及安全性。方法收集接受经导管动脉栓塞(transcatheter arterial chemoembolization,TACE)治疗的原发性肝癌患者。接受聚乙烯醇载药微球治疗的48例为观察组,接受碘化油+化疗药治疗的56例为对照组。比较两组患者术后肝功能情况、甲胎蛋白(alpha fetoprotein,AFP)浓度、肿瘤坏死率、近期疗效及不良反应。结果观察组和对照组术后肝功能指标一过性增高。两组术后AFP浓度比较,差异无统计学意义(P>0.05),但均低于术前AFP浓度(均P<0.01)。观察组肿瘤坏死率高于对照组[(85.20±12.83)%vs(49.07±15.24)%,P=0.027]。治疗后1个月,观察组和对照组疾病缓解率分别为77.0%(37/48)和48.2%(27/56),两组比较差异具有统计学意义(P=0.003)。观察组术后不良反应发生率较对照组少(P<0.05)。结论聚乙烯醇载药微球治疗原发性肝癌效果明显,术后不良反应少。
Objective To investigate the efficacy and safety of polyvinyl alcohol callispheres in interventional embolization therapy for primary hepatocellular carcinoma.Methods Among patients with primary hepatocellular carcinoma treated with transcatheter arterial chemoembolization(TACE),48 patients treated with polyvinyl alcohol callispheres were considered as the observation group and 56 patients treated with lipiodol+chemotherapy were served as the control group.The liver function,alpha fetoprotein(AFP)concentration,tumor necrosis rate,short-term efficacy and adverse reactions were compared between the two groups.Results The indexes of liver function in the observation group and the control group increased temporarily after operation.AFP concentration showed no statistical difference between the two groups(P>0.05),but was lower than that before operation in both groups(both P<0.05).The tumor necrosis rate in the observation group was higher than that in the control group[(85.20±12.83)%vs(49.07±15.24)%,P=0.027].One month after treatment,the disease remission rate of the observation group and control group were 77.0%(37/48)and 48.2%(27/56),respectively,with a statistically significant difference(P=0.003).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusions Polyvinyl alcohol callispheres have obvious effects in the treatment of primary hepatocellular carcinoma,and have less postoperative adverse reactions.
作者
黄文浩
冯广森
Huang Wenhao;Feng Guangsen(Intervention D epartment,The Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China)
出处
《实用肿瘤杂志》
CAS
2020年第3期260-264,共5页
Journal of Practical Oncology
