摘要
噁唑类化合物可通过非共价相互作用与生物系统中的各种酶及受体结合,显示出多种多样的生物活性,其在抗肿瘤领域的相关研究取得了许多优秀的成果。现综述近年来国内外关于噁唑类化合物作为抗肿瘤类潜在药物的研究进展,并展望了以噁唑为基础的化合物作为抗肿瘤药物的研究和开发前景。
Oxazole compounds are readily able to bind with a variety of enzymes and receptors in biological system via diverse non-covalent interactions,thus to display versatile biological activities.The perspectives of the foreseeable future in the research and development of oxazole-based antitumor compounds are also presented.It was expected that this review would serve as a stimulant for new thoughts in the quest for rational designs of more active and less toxic oxazole medicinal drugs.
作者
刘芸竹
张慧珍
周成合
LIU Yunzhu;ZHANG Huizhen;ZHOU Chenghe(School of Pharmacy,Linyi University,Linyi,Shandong,276000 P.R.China;School of Chemistry and Chemical Engineering,Southwest University,Chongqing,400715 P.R.China)
出处
《华西药学杂志》
CAS
CSCD
2020年第3期325-337,共13页
West China Journal of Pharmaceutical Sciences
基金
山东省重点研发计划项目(2019GSF108216)
临沂大学博士启动基金(LYDX2016BS030)。
关键词
噁唑
异噁唑
噁二唑
苯并噁唑
苯并异噁唑
抗肿瘤
研究进展
Oxazoles
Isoxazoles
Oxadiazoles
Benzoxazoles
Benzoisoxazole
Antitumor
Research progress
