摘要
目的探索乌拉地尔联合硝酸甘油对老年高血压急症患者血压的影响。方法选择2016年7月至2018年9月永康市第一人民医院收治的老年高血压急症患者60例为观察对象,按照随机数字表法分为对照组和观察组,每组30例。对照组应用硝酸甘油静脉滴注治疗,观察组在对照组基础上应用静脉微泵注射盐酸乌拉地尔注射液。对比两组患者入组时及治疗60 min后的总有效率、舒张压、收缩压和心率,比较两组患者不良反应发生情况。结果观察组治疗有效率为96.67%,明显高于对照组的76.67%,差异有统计学意义(χ^2=5.19,P<0.05)。入组时两组患者血压、心率差异均无统计学意义(均P>0.05),治疗后,两组患者血压均明显下降(均P<0.05),且观察组下降水平明显优于对照组,差异均有统计学意义(均P<0.05)。观察组患者心率明显降低,改善情况优于对照组(P<0.05)。观察组不良反应发生率(10.00%)显著低于对照组(33.33%),差异有统计学意义(χ^2=4.81,P<0.05)。结论静脉微泵注射盐酸乌拉地尔注射液联合硝酸甘油治疗老年高血压急症降压效果显著,不良反应少,安全性高。
Objective To explore the effect of urapidil combined with nitroglycerin on blood pressure in elderly patients with acute hypertension.Methods From July 2016 to September 2018,60 elderly patients with acute hypertension admitted to the First People's Hospital of Yongkang were selected as the observation objects.They were divided into control group and observation group according to random number table method,with 30 cases in each group.The control group was treated with nitroglycerin intravenous drip,while the observation group was treated with urapidil hydrochloride injection by intravenous micropump on the basis of the control group.The total effective rate,diastolic blood pressure,systolic blood pressure and heart rate were compared between the two groups at the time of admission and 60 minutes after treatment.Results The effective rate of the observation group was 96.67%,which was significantly higher than 76.67%of the control group(χ^2=5.19,P<0.05).There were no statistically significant differences in blood pressure and heart rate between the two groups at the time of admission(all P>0.05).After treatment,the blood pressure of the two groups decreased significantly(all P<0.05),and the decrease levels of the observation group was significantly better than those of the control group,the difference were statistically significant(all P<0.05).The heart rate of the observation group was significantly lower than that of the control group(P<0.05).The incidence of adverse reactions in the observation group(10.00%)was significantly lower than that in the control group(33.33%),and the difference was statistically significant(χ^2=4.81,P<0.05).Conclusion Intravenous micropump injection of urapidil hydrochloride injection combined with nitroglycerin has remarkable antihypertensive effect,less adverse reactions and high safety in the treatment of elderly patients with acute hypertension.
作者
徐军鹏
Xu Junpeng(Department of Emergency,the First People's Hospital of Yongkang,Yongkang,Zhejiang 321300,China)
出处
《中国基层医药》
CAS
2020年第10期1181-1184,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
高血压
急症
血压
疗效比较研究
输注泵
老年人
乌拉地尔
硝酸甘油
Hypertension
Emergencies
Blood pressure
Comparative effectiveness research
Infusion Pumps
Aged
Urapidil
Nitroglycerin
