摘要
为观察右美托咪定联合帕瑞昔布钠在结直肠癌患者术后的应用效果,将结肠癌患者70例随机分为对照组和观察组,每组35例。对照组静脉注射右美托咪定,观察组在对照组基础上静脉注射帕瑞昔布钠,观察比较2组患者临床相关指标,VAS评分及术后不良反应发生情况。结果显示,观察组麻醉时间、拔管时间及苏醒时间均短于对照组(P<0.05)。术前2组患者疼痛评分比较差异无统计学意义(P>0.05),术后1h、4h、8h、12h观察组疼痛评分均低于对照组(P<0.05)。2组患者术后恶心呕吐、过度镇静等不良反应发生率比较差异无统计学意义(P>0.05)。结果表明,右美托咪定联合帕瑞昔布钠可有效缓解结直肠癌患者术后疼痛,明显缩短麻醉、拔管及苏醒时间,且术后无明显不良反应,安全性较高,对促进患者术后病情康复具有重要作用。
This study was to observe the application efficacy after procedure for colorectal cancer,randomly divided 70 patients with colorectal cancer into control group[35 cases,intravenous injection of Dexmedetomidine(DEX)]and observation group(35 cases,DEX plus parecoxib sodium,intravenously injecting);then,observed and compared both groups’clinical relevant norms,the score on VAS,and postoperative untoward reaction incidence status.As results,in the pain score before procedure and in untoward reaction(e.g nausea,vomiting and oversedation,etc)incidence after procedure there all was no statistical difference between the two groups(P>0.05);but in the time for anesthesia,for extubation and for emergence;and in the pain score at 1,4,8 and 12 hrs.after procedure observation group was respectively shorter and lower than control group(all,P<0.05).Results show that DEX plus parecoxib sodium after procedure for colorectal cancer can effectively relieve patients’pain,significantly shorten the time for anesthesia,for extubation and for emergence;and has no distinct untoward reaction;and its safety is more higher,has important role on promoting condition for rehabilitation.
作者
张启东
杨富平
ZHANG Qi-dong;YANG Fu-ping(Pharmacy Dept.,the 2nd Affiliated Hospital to Henan Sci-tech University,Luoyang,Henan 471003)
出处
《中国肛肠病杂志》
2020年第3期18-19,共2页
Chinese Journal of Coloproctology
关键词
结直肠癌
手术
右美托咪定
帕瑞昔布钠
Colorectal cancer
Procedure
Dexmedetomidine
Parecoxib sodium
