摘要
目的探讨四肢开放性骨折患者伤口分泌物细菌培养与药敏试验对抗生素合理使用的影响。方法80例接受抗菌药物治疗的四肢开放性骨折患者随机分为两组各40例,观察组患者根据伤口分泌物细菌培养与药敏试验结果给予抗生素,对照组患者根据经验给予抗生素,比较两组患者的用药合理性及不良反应。结果观察组的药物选择合理、用药途径合理、用药剂量合理、用药频次合理比例均显著高于对照组,总不良反应发生率显著低于对照组(P<0.05)。结论对四肢开放性骨折患者,根据伤口分泌物细菌培养与药敏试验结果合理应用抗生素,可降低患者的感染风险。
Objective To explore the effect of bacterial culture and drug sensitivity test of wound secretion on the rational use of antibiotics in patients with open fractures of extremities.Methods 80 patients with open fractures of extremities treated with antibiotics were randomly divided into two groups,with 40 cases in each group.The observation group was given antibiotics according to the results of bacterial culture and drug sensitivity test of wound secretion,while the control group was given antibiotics according to experience.The rationality of drug use and adverse reaction were compared between the two groups.Results The proportions of rational drug selection,rational medication routes,rational medication dosage and rational medication frequency in the observation group were significantly higher than those in the control group,and the total incidence of adverse reactions was significantly lower than that in the control group(P<0.05).Conclusions For patients with open fractures of extremities,reasonable application of antibiotics according to the results of bacterial culture and drug sensitivity test of wound secretion can reduce the risk of infection of patients.
作者
郑燕辉
刘卫明
郑春燕
ZHENG Yanhui;LIU Weiming;ZHENG Chunyan(Clinical Laboratory,the Traditional Chinese Medicine Hospital of Longchuan County,Heyuan 517300,China;3^rd Department of Orthopedics,the Traditional Chinese Medicine Hospital of Longchuan County,Heyuan 517300,China;1^st Department of Orthopedics,the Traditional Chinese Medicine Hospital of Longchuan County,Heyuan 517300,China)
出处
《临床医学工程》
2020年第6期731-732,共2页
Clinical Medicine & Engineering
基金
2019年河源市社会发展科技计划项目“伤口分泌物病原菌培养与药敏试验指导开放性骨折患者术后抗生素的应用价值”(项目编号:河科[2019]55号-83)。
关键词
四肢开放性骨折
伤口分泌物
细菌培养
药敏试验
抗生素
耐药性
Open fractures of extremities
Wound secretion
Bacterial culture
Drug sensitivity test
Antibiotics
Drug resistance
