摘要
目的观察中药熏蒸联合地奈德乳膏治疗小儿慢性湿疹血虚证的临床疗效。方法选取2016年6月至2018年5月于杭州市第三人民医院皮肤科诊治的慢性湿疹血虚证患儿110例,按随机数字表法分为对照组和治疗组,各55例。对照组外用地奈德乳膏治疗,治疗组在对照组治疗方法的基础上联合中药熏蒸治疗,2组均治疗7 d后,比较临床疗效、临床症状改善情况及血清炎症因子水平。随访6个月,比较2组的复发率。结果治疗组总有效率为89.09%(49/55),显著高于对照组的69.09%(38/55),2组比较,差异有统计学意义(P<0.05)。治疗前,2组的湿疹面积及严重度指数(EASI)、瘙痒程度和中医证候积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组的EASI、瘙痒程度和中医证候积分均较同组治疗前明显下降,差异均有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。治疗前,2组白细胞介素-4(IL-4)、白细胞介素-10(IL-10)及肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组IL-4、IL-10及TNF-α水平均较同组治疗前明显降低,差异有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。随访6个月,治疗组复发率为6.12%(3/49),明显低于对照组的23.68%(9/38),差异有统计学意义(P<0.05)。结论中药熏蒸联合地奈德乳膏治疗小儿慢性湿疹血虚证,可有效改善临床症状,提高临床疗效,降低炎症反应,且复发率低,值得临床推广应用。
Objective To observe the clinical efficacy of Chinese materia medica(CMM) fumigant combined with desonide cream in the treatment of chronic eczema in children with blood-deficiency syndrome.Methods From June 2016 to May 2018, totally 110 chronic eczema in children with blood-deficiency syndrome diagnosed and treated in dermatology department of Hangzhou the Third People’s Hospital were divided into control group and treatment group according to random number table method,with 55 cases in each.The control group was given desonide cream for external use,while the treatment group was given CMM fumigant on the basis of the control group.After both were treated for 7 days,the clinical efficacy,improvement of clinical symptoms and levels of inflammatory factors of the 2 groups were compared.After 6 months of follow-up,the recurrence rate of the 2 groups were compared.Results The total effective rate of the treatment group was 89.09%(49/55),which was significantly higher than 69.09%(38/55) of the control group,and the difference between the 2 groups was statistically significant(P<0.05).Before treatment, the difference was not statistically significant in eczema area and severity index(EASI),itching degree and TCM symptom scores between the 2 groups(P>0.05),and they were comparable.After treatment,EASI,itching degree and TCM symptom scores of the 2 groups all significantly decreased compared with the same group before treatment, and the difference was statistically significant(P<0.05),moreover,the treatment group decreased more significantly(P<0.05).Before treatment, the difference was not statistically significant in the levels of interleukin-4(IL-4),interleukin-10(IL-10) and tumor necrosis factor-α(TNF-α) between the 2 groups(P>0.05),and they were comparable.After treatment,the levels of IL-4,IL-10 and TNF-α of the 2 groups significantly decreased compared with the same group before treatment,and the difference was statistically significant(P<0.05),moreover,the treatment group decreased more significantly(P<0.05).After 6 months of follow-up,the recurrence rate of the treatment group was 6.12%(3/49) which was significantly lower than 23.68%(9/38) of the control group, and the difference was statistically significant(P<0.05).Conclusion It can effectively improve the clinical efficacy and clinical symptoms,reduce inflammation response to use CMM fumigant combined with desonide cream in the treatment of chronic eczema in children with blood-deficiency syndrome,moreover,the recurrence rate is low,which deserves clinical promotion and application.
作者
陈书悦
单筠筠
徐田红
温伟为
黄骏
CHEN Shuyue;SHAN Yunyun;XU Tianhong;WEN Weiwei;HUANG Jun(Department of Dermatology,Hangzhou the Third People's Hospital,Hangzhou,Zhejiang,310009,China)
出处
《中医儿科杂志》
2020年第3期55-58,共4页
Journal of Pediatrics of Traditional Chinese Medicine
关键词
慢性湿疹
小儿
血虚证
中药熏蒸
地奈德乳膏
临床观察
chronic eczema
children
Chinese materia medica(CMM)fumigant
desonide cream
clinical observation
