摘要
目的:探究牙周病患者应用盐酸米诺环素软膏、甲硝唑药膜联合治疗的疗效以及安全性。方法:2017年2月~2018年4月在某院口腔科接受牙周病治疗的患者中随机抽取86例,应用随机双盲法将抽取对象分为参考组和探究组各43例,参考组患者冲洗牙周后于局部放置甲硝唑药膜,探究组患者应用甲硝唑药膜联合盐酸米诺环素软膏治疗,比较两组患者临床治疗效果以及用药安全性。结果:探究组患者牙周附着水平低于参考组患者,差异存在统计学意义(t=8.7362,P=0.0453);菌斑指数低于参考组患者,差异存在统计学意义(t=10.2439,P=0.0185);牙龈指数低于参考组患者,差异存在统计学意义(t=17.2746,P=0.0019);探究组患者牙周袋探诊深度明显较参考组患者小,差异存在统计学意义(t=17.2746,P=0.0019);探究组患者病情总好转率为97.67%,明显较参考组患者83.72%高,两组患者临床疗效经对比差异有统计学意义(χ^2=9.6140,P=0.0089);参考组患者用药后不良反应总发生率为9.30%,探究组总发生率为6.98%,两组患者用药安全性差异不显著且无统计学意义(χ^2=2.0093,P=0.0676)。结论:牙周病患者应用盐酸米诺环素软膏、甲硝唑药膜联合治疗疗效更佳且安全可靠。
Objective:To investigate the efficacy and safety of minocycline hydrochloride ointment and metronidazole membrane in the treatment of periodontitis.Methods:86 patients with periodontitis treated in a hospital from February 2017 to April 2018 were randomly selected and divided into reference group(n=43)and inquiry group(n=43)by random double-blind method.The patients in the reference group were treated with metronidazole membrane after the periodontal irrigation,and the patients in the inquiry group were treated with metronidazole membrane and minocycline hydrochloride ointment,then the clinical efficacy and safety between the two groups were compared.Results:The level of periodontal attachment in the inquiry group was lower than that in the reference group,the difference was statistically significant(t=8.7362,P=0.0453).The plaque index was lower than the reference group,the difference was statistically significant(t=10.2439,P=0.0185).The gingival index was lower than that of the reference group,and there was a significant difference(t=17.2746,P=0.0019).The probing depth of periodontal pocket in the inquiry group was significantly smaller than that in the reference group,and the difference was statistically significant(t=17.2746,P=0.0019).The total improvement rate of the patients in the inquiry group was significantly higher than that in the control group(97.67%vs 83.72%).The clinical efficacy of the two groups was comoared and the difference between the two groups was statistically significant(χ^2=9.6140,P=0.0089).The total incidence of adverse reactions was 9.30%in the reference group and 6.98%in the inquiry group.There was no significant difference in drug safety between the two groups(χ^2=2.0093,P=0.0676).Conclusion:Minocycline hydrochloride ointment combined with metronidazole membrane is more effective and safe in the treatment of periodontitis.
作者
王伟涛
Wang Weitao(Luoyang No.2 Hospital of traditional Chinese Medicine,Luoyang 471003)
出处
《数理医药学杂志》
2020年第7期1011-1013,共3页
Journal of Mathematical Medicine
关键词
盐酸米诺环素软膏
甲硝唑药膜
牙周病
临床疗效
治疗安全性
minocycline hydrochloride ointment
metronidazole membrane
periodontal disease
clinical efficacy
therapeutic safety
