摘要
目的:探讨肝苏颗粒联合恩替卡韦对乙型肝炎肝硬化患者血清生长激素、免疫功能及临床证候的影响。方法:选取乙型肝炎肝硬化患者285例,采用随机数字表法将患者分为对照组(n=142)和研究组(n=143),对照组患者给予恩替卡韦治疗,研究组在对照组基础上加用肝苏颗粒治疗,比较两组患者的临床疗效、血清生长激素、免疫功能、临床证候及不良反应。结果:研究组患者治疗6个月后的临床疗效为87.41%(125/143),明显高于对照组68.31%(97/142)(P<0.05)。两组治疗6个月后CD8^+降低,CD3^+、CD4^+、CD4^+/CD8^+均升高(P<0.05),研究组患者CD8^+低于对照组,CD3^+、CD4^+、CD4^+/CD8^+则高于对照组(P<0.05)。研究组患者治疗6个月后血清生长激素(GH)水平较治疗前降低,且低于对照组(P<0.05)。两组患者治疗6个月后两胁胀满、乏力、体重减轻、纳差症状评分均下降,且研究组低于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:肝苏颗粒联合恩替卡韦治疗乙型肝炎肝硬化,可迅速改善患者临床症状、GH水平及机体免疫功能,疗效确切,且不增加不良反应发生率,临床应用价值较高。
Objective:To explore the effect of Gansu Granule combined with entecavir on serum growth hormone,immune function and clinical syndromes in patients with hepatitis B cirrhosis.Methods:285 patients with hepatitis B cirrhosis who were admitted to our hospital from February 2017 to January 2019 were selected,they were divided into control group(n=142)and study group(n=143)by random number table method.The control group was treated with entecavir,and the study group was treated with Gansu Granule on the basis of the control group.The clinical efficacy,serum growth hormone,immune function,clinical syndromes and adverse reactions were compared between the two groups.Results:The clinical efficacy of the study group was 87.41%(125/143)after 6 months of treatment,which was significantly higher than 68.31%(97/142)of the control group(P<0.05).After 6 months of treatment,CD8^+ decreased and CD3^+,CD4^+,CD4^+/CD8^+ increased in both groups(P<0.05).CD8^+ in the study group was lower than that in the control group,while CD3^+,CD4^+,CD4^+/CD8^+ in the study group was higher than that in the control group(P<0.05).The serum growth hormone(GH)level in the study group was lower than that in the control group 6 months after treatment(P<0.05).After 6 months of treatment,the scores of bilateral flatulence,fatigue,weight loss and poor acceptance symptoms in both groups decreased,and those in the study group were lower than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Gansu Granule combined with entecavir in the treatment of hepatitis B cirrhosis can rapidly improve the clinical symptoms,GH level and immune function of patients with exact effect,and does not increase the incidence of adverse reactions,clinical application value is higher.
作者
尹诗
夏仁兴
陈俊西
谢安卫
YIN Shi;XIA Renxing;CHEN Junxi(Department of Traditional Chinese Medicine,Huaxi Guang'an Hospital,Sichuan University,Guang'an Sichuan,638000 China;不详)
出处
《中西医结合肝病杂志》
CAS
2020年第3期211-214,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
