摘要
目的通过分析云南省昆明市临床病理特征下喉癌生存率情况,探讨影响喉癌发生、发展及预后的相关因素。方法收集2010年3月至2015年3月5年期间昆明市各三甲医院收治的喉癌病例资料。进行数据处理,计算生存率,检验各组间的生存曲线的差异。结果200例喉癌患者的中位生存时间为46.6月(P25-75:35.1~67.9月)。喉癌总体生存率(Overall Survival,OS)1年、3年和5年分别为91.2%、84.9%和76.8%。喉癌疾病特异生存率(Disease-Specific Survival,DSS)1年、3年和5年分别为90.7%.84.1%和77.6%,45例声门上型喉癌的1年、3年和5年OS分别为83.7%、75.9%和61.2%。1年、3年和5年DSS分别为8304%、74.8%和60.5%,153例声门型喉癌的OS分别1年、3年和5年为88.7%、86.2%和81.3%。DSS分别1年、3年和5年为89.3%、86.1%和79.4%。T1、T2、T3、T4期喉癌的3年OS分别为87.9%、83,7%、73.5%和63.0%,3年DSS分别为93.6%、83.1%、76.9%和64.9%,5年OS分别为82.3%、78.2%、65.7%和49.6%,5年DSS分别为90.1%、75.4%、63.2%和52.1%。I、II、III、IV期喉癌的3年OS分别为95.2%、88.3%、75.6%和69.1%,3年DSS分别为95.7%、84.9%、80.4.5%和70.3%,5年OS分别为88.7%、80.2%、71.5%和50.3%,5年DSS分别为91.6%、74.8%、71.4%和51.9%,结论本研究发现肿瘤的各种临床特点及病理分型、生活习惯、治疗方法的不同等均是影响喉癌患者预后的重要因素,同时对生存率调查也有一定影响,我们还需要对肿瘤发生、发展的流行病学及分子生物学的特征进一步分析了解是否存在其他影响喉癌生存率及相关因素。
Objective To analyze the survival rate of laryngeal cancer in Kunming,Yunnan Province,and to explore the related factors affecting the occurrence,development and prognosis of laryngeal cancer Methods Data of laryngeal cancer cases admitted to hospitals of Kunming from March 2010 to March 2015 were collected.Data were processed,survival rates were calculated and survival curves were tested.Results The median survival time of 200 patients with laryngeal cancer was 46.6 months(P25-75:35.1-67.9).Overall Survival(OS)was 91.2%,84.9%and 76.8%respectively.Disease-Specific Survival(DSS)was 91.7%,84.1%and 77.6%in 1,3 and 5 years respec-tively.OS of 45 cases of supraglottic laryngeal cancer was 83.7%,75.9%and 61.2%in 1,3 and 5 years respectively.DSS was 83.04%,74.8%and 60.5%in 1,3 and 5 years,respectively.OS of 153 cases of glottic laryngeal cancer in 1,3 and 5 years was 89.4%,87.9%and 82.3%respectively.DSS in 1 year,3 years and 5 years were 87.6%,86.1%and 79.4%respectively.The 3-year OS of stage T1,T2,T3 and T4 laryngeal cancer were 87.9%,83.7%,73.5%and 63.0%respectively,the three-year DSS were 93.6%,83.1%,76.9%and 64.9%,the 5-year OS were 82.3%,78.2%,65.7%and 49.6%,and the 5-year DSS were 90.1%,75.4%,63.2%and 52.1%,respectively.3-year OS was 95.2%,88.3%,75.6%and 69.1%for stage I,II,III and IV laryngeal cancer,3-year DSS was 96.1%,85.6%,77.5%and 68.3%,five-year OS was 89.4%,77.9%,67.8%and 49.8%,5-year DSS was 90.3%,75.8%,71.4%and 51.9%,respec-tively.Conclusions The survival rate of this group is slightly different from that of other studies.What are the factors affecting survival?We also need to analyze the epidemiological and molecular biological characteristics of the tumors at different stages.
作者
林雁
王明源
何晓光
温巾雅
陈婷瑞
杨声豪
黄成
张京晶
Lin Yan;Wang Mingyuan;He Xiaoguang;Wen Jinya;Chen Tingrui;Yang Shenghao;Huang Cheng;Zhang Jingjing(Department of Otolaryngology,Head&Neck Surgery,First affiliated Hospital of Kunming Medical University,Yunnan,Kunming,650032,China;Department of Community,School of Public Health,Kunming Medical University,Yunnan,Kunming,650500,China)
出处
《中国医学文摘（耳鼻咽喉科学）》
2020年第3期176-179,共4页
Chinese Medical Digest(Otorhinolaryngology)
基金
云南省教育厅科研基金资助项目(2016ZZX098)
云南省哲学社会科学规划项目(YB2019064)
云南省教育厅科研基金资助项日(2016ZZX091)
云南省科技厅一昆明医科大学应用基础研究联合专项资金项目(2018EE001(-042))
昆明医科大学教研教改重点项目(2019-JY-Z-11)。
关键词
喉癌
生存率
临床病理
Laryngeal cancer
Survival rate
Clinical pathology
