摘要
目的:观察醒脑开窍针法联合奥拉西坦胶囊治疗非痴呆性血管性认知障碍的临床疗及其可能的作用机制。方法:将符合纳入标准的60例非痴呆性血管性认知障碍患者按照随机数字表分为西药组(口服奥拉西坦)、针药组(口服奥拉西坦+醒脑开窍针),各30例。治疗4周后进行临床效果评价,观察指标为相关安全性指标、相关临床指标、实验室相关检查。结果:治疗后,西药组临床有效率为56.67%(17/30),针药组临床有效率为70%(21/30),差异有统计学意义;治疗后,两组相关安全性指标肝功(ALT、AST、AKP)、肾功(Cr、BUN)比较,差异无统计学意义(P>0.05);治疗后,两组蒙特利尔认知评估量表(MoCA)、简易智能精神状态检查量表(MMSE)、日常生活能力量表(ADL)积分均提高,且针药组均优于西药组,差异均有统计学意义(P<0.05);治疗后,两组实验室指标血清降钙素基因相关肽(CGRP)升高,视锥蛋白样蛋白-1(VILIP-1)降低,差异均有统计学意义(P<0.05)。结论:醒脑开窍针法治疗非痴呆性血管性认知障碍能够有效的改善患者的认知功能,提高日常生活能力,其机制可能与CGRP和VILIP-1的表达相关。
Objective:To observe the clinical effect and mechanism of Xingnao Kaiqiao acupuncture combined with Oxiracetam Capsule in the treatment of vascular cognitive impairment no-dementia.Methods:60 patients with vascular cognitive impairment no-dementia were randomly divided into the control group and the study group,with 30 cases in each group.The control group was treated with Oxiracetam Capsule;on which basis,the study group was also treated with Xingnao Kaiqiao acupuncture.After four weeks of treatment,the clinical effect,related safety indexes and laboratory indexes were evaluated.Results:The clinical effective rate of the study group was 70%(21/30),which was significantly higher than 56.67%(17/30)of the control group(P<0.05).After the treatment,there were no statistical differences in ALT,AST,AKP,Cr and BUN between the two groups(P>0.05).The scores of MoCA,MMSE and ADL were increased after the treatment in the two groups;the increases in the study group were more significant(P<0.05).The serum CGRP was increased and serum VILIP-1 was decreased after the treatment in the two groups(P<0.05).Conclusion:Xingnao Kaiqiao acupuncture can effectively improve the patients’cognitive function and daily living ability in the treatment of non-demented vascular cognitive impairment.The mechanism may be related to the expressions of CGRP and VILIP-1.
作者
曲冰
王丰
李晓陵
曹丹娜
刘晓慧
姜晓旭
蔡丽娜
杨旭
高瑞雪
QU Bing;WANG Feng;LI Xiaoling;CAO Danna;LIU Xiaohui;JIANG Xiaoxu;CAI Lina;YANG Xu;GAO Ruixue(The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China;Heilongjiang University of Chinese Medicine, Harbin 150040, China;The Affiliated Hospital of Qingdao Binhai University, Qingdao 266540, China)
出处
《中医药信息》
2020年第4期72-75,共4页
Information on Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81973930,81373714)
黑龙江省自然科学基金面上项目(H2016081)
哈尔滨市科技创新人才优秀学科带头人基金(2016RAXYJ096)
教育部“春晖计划”(Z2009-1-15030)
哈尔滨市科技创新人才专项资金项目(2017RAQXJ180)。
关键词
醒脑开窍针法
非痴呆性血管性认知障碍
临床观察
Xingnao Kaiqiao acupuncture
Vascular cognitive impairment no-dementia
Clinical observation
