摘要
目的研究血浆脂蛋白相关磷脂酶A2(LP-PLA2)水平与高血压患者分层及动脉粥样硬化(AS)程度的关系。方法选取2016年3月~2019年3月上海市岳阳中西医结合医院闵行分院(以下简称"我院")收治的100例高血压患者作为观察组,另取同期于我院接受体检的健康人员100名作为对照组。将观察组患者按照心血管病危险水平分层标准分成低危组(16例)、中危组(23例)、高危组(21例)以及极高危组(40例),记录两组基本资料、血脂水平、血浆LP-PLA2水平及脉搏波传导速度(PWV)。分析高血压患者血浆LP-PLA2水平与PWV的相关性。结果观察组收缩压、舒张压、低密度脂蛋白胆固醇和总胆固醇水平高于对照组,三酰甘油和高密度脂蛋白胆固醇水平低于对照组,差异有统计学意义(P <0.05)。观察组LP-PLA2、PWV明显高于对照组,差异有统计学意义(P <0.05)。极高危组LP-PLA2、PWV明显高于低危组、中危组、高危组,差异有统计学意义(P <0.05)。经Pearson相关性分析可得,高血压患者血浆LP-PLA2水平与PWV呈正相关(r=0.643,P <0.05)。结论高血压患者血浆LP-PLA2水平上升,与患者危险分层及AS程度密切相关,检测血浆LP-PLA2水平可以指导患者的早期治疗。
Objective To investigate the relationship between plasma lipoprotein related phospholipase A2(LP-PLA2 level and the stratification and the degree of atherosclerosis(AS)in hypertensive patients.Methods A total of 100 cases of hypertension patients admitted to Minhang Branch of Shanghai Yueyang Integrated Traditional Chinese and Western Medicine Hospital("our hospital"for short)from March 2016 to March 2019 were selected as the observation group,and another 100 cases of healthy personnel who received physical examination in our hospital during the same period were selected as the control group.The patients in the observation group were divided into low-risk group(16 cases),medium risk group(23 cases),high-risk group(21 cases)and extremely high-risk group(40 cases)according to the stratification standard of cardiovascular disease risk level.The basic data,blood lipid level,plasma LP-PLA2 and pulse wave velocity(PWV)levels were recorded.The correlation between plasma Lp-PLA2 and PWV in hypertension patients was analyzed.Results The levels of systolic blood pressure,diastolic blood pressure,low density lipoprotein and total cholesterol in the observation group were significantly higher than those in the control group,while the levels of triglyceride and high density lipoprotein were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).The levels of plasma LP-PLA2 and PWV in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).The levels of plasma LP-PLA2 and PWV of patients in the extremely high-risk group were significantly higher than the low-risk group,the medium-risk group and the high-risk group,and the difference was statistically significant(P<0.05).Pearson correlation analysis showed that plasma LP-PLA2 level was positively correlated with PWV level in hypertension patients(P<0.05).Conclusion The increase of plasma LP-PLA2 level in hypertension patients is closely related to the risk stratification and AS degree.The detection of plasma Lp-PLA2 level can guide the early treatment of patients.
作者
张军
孙惠芳
刘小利
ZHANG Jun;SUN Huifang;LIU Xiaoli(Department of Laboratory,Minhang Branch of Shanghai Yueyang Integrated Traditional Chinese and Western Medicine Hospital,Shanghai 200241,China)
出处
《中国医药导报》
CAS
2020年第17期141-144,共4页
China Medical Herald
基金
上海市卫生和计划生育委员会科研课题(M20170085)。
关键词
高血压
动脉粥样硬化
脂蛋白相关磷脂酶A2
相关性
血浆
Hypertension
Atherosclerosis
Lipoprotein associated phospholipase A2
Correlation
Plasma
