摘要
为提高辅酶Q10(CoQ10)的透皮吸收效果,以辛酸/癸酸甘油三酯(GTCC)为液体脂质、鲸蜡醇棕榈酸酯(CP)为固体脂质,制备了不同质量分数固体脂质(以固液脂质的总质量为基准,下同)的Co Q10-脂质纳米囊,并对其稳定性及透皮性能进行了考察。结果表明,固体脂质的添加未对CoQ10-脂质纳米囊的粒径及储藏稳定性产生影响,粒径均为52 nm左右,储藏180 d后其粒径及外观均无明显变化;FTIR结果表明,Co Q10与脂质纳米囊之间未发生化学反应且能被很好地包埋在脂质纳米囊中;通过闭合效应、体外透皮实验及激光共聚焦的观察发现,当CP的质量分数增加至70%和95%时,Co Q10-脂质纳米囊能显著减少皮肤水分的蒸发,并更好地促进Co Q10透皮吸收,使表皮层和真皮层的荧光强度明显增强。
In order to improve the transdermal delivery of coenzyme Q10(CoQ10),CoQ10 nanocapsules with different mass fractions of solid lipids(based on the total mass of solid and liquid lipids,the same below)were prepared using caprylic/caprate triglyceride(GTCC)as liquid lipid and cetyl palmitate(CP)as solid lipid.The stability and transdermal properties of the samples were studied.The results showed that the addition of solid lipids had no effect on the particle size and storage stability of CoQ10 nanocapsules.The particle size of CoQ10 nanocapsules with different mass fractions of solid lipids was about 52 nm.After storage for 180 days,there was no significant change in particle size and appearance of Co Q10 nanocapsules.FTIR results revealed that there was no chemical reaction between CoQ10 and lipid nanocapsules,and CoQ10 could be well encapsulated in nanocapsules.The results of occlusive effects,in vitro transdermal test,and laser confocal microscopy indicated that when the mass fraction of CP increased to 70%and 95%,the prepared CoQ10 nanocapsules could significantly reduce the evaporation of skin water,promote the transdermal absorption of Co Q10,and enhance the fluorescence intensity of the epidermal layer and the dermal layer.
作者
谢桂杰
梁蓉
杨成
XIE Guijie;LIANG Rong;YANG Cheng(School of Chemical and Material Engineering,Jiangnan University,Wuxi 214122,Jiangsu,China;Key Laboratory of Synthetic and Biological Colloids,Ministry of Education,Jiangnan University,Wuxi 214122,Jiangsu,China)
出处
《精细化工》
EI
CAS
CSCD
北大核心
2020年第6期1242-1248,共7页
Fine Chemicals
基金
国家重点研发计划资助(2016YFD0400801)。
