摘要
MetarhizosidesA-G(1-7),seven new polysubstituted phenyl glucosides,were isolated from the extracts of solid rice medium of a marine-derived fungus Metarrhizium anisopliae.Compounds 1-7 all contain a polysubstituted phenyl group and the sugar unit is identified as 4'-O-methyl-β-D-glucopyranose.Their structures were elucidated by NMR spectroscopy and chemical method.These compounds were evaluated for anti-inflammatory activity by using LPS-stimulated murine macrophage RAW 264.7 cells and the cytotoxicities against four human cancer cell lines.
基金
This work was financially supported by the Program for Changjiang Scholars of Ministry of Education of the People's Republic of China(No.T2016088)
the National Natural Science Foundation for Distinguished Young Scholars(No.81725021)
the National Natural Science Foundation of China(No.31900288)
the Program from the(hina Postdoctoral Science Foundation(No.2019M652660)
the Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College(HUST,China).
