摘要
目的:观察补肺益肾平喘方治疗肺肾阴虚证小儿哮喘持续状态的临床疗效。方法:采用随机数字表法将64例肺肾阴虚证哮喘持续状态患儿随机分为2组,对照组32例采用临床综合疗法,观察组32例在对照组治疗基础上给予补肺益肾平喘方治疗。治疗7 d后,比较2组主要症状体征消失时间、肺功能指标、血清炎性因子水平,统计2组临床疗效。结果:观察组总有效率为93.7%,高于对照组的71.9%(P<0.05)。治疗后,观察组喘息、咳嗽、呼吸困难、肺部哮鸣音消失时间均明显短于对照组(P<0.01);2组最高呼气流速(PEFR)、第1秒用力呼气量(FEV1)、用力肺活量(FVC)均显著升高(P<0.01),观察组以上肺功能指标升高更明显(P<0.01);2组血清白细胞介素-4 (IL-4)、嗜酸性粒细胞阳离子蛋白(ECP)水平均显著降低(P<0.01),γ-干扰素(IFN-γ)水平均显著升高(P<0.01),观察组以上血清炎性指标改善更明显(P<0.01)。结论:补肺益肾平喘方能够抑制肺肾阴虚证哮喘持续状态患儿机体炎性反应,改善肺功能,对于缓解临床症状具有明显疗效。
Objective: To observe the clinical effect of Bufei Yishen Pingchuan prescription for persistent asthma with lung-kidney yin deficiency syndrome in children. Methods:A total of 64 cases of children with persistent asthma with lungkidney yin deficiency syndrome were divided into two groups according to random number table method,32 cases in each group. The control group was given clinical comprehensive therapy,and the observation group was additionally given Bufei Yishen Pingchuan prescription. After seven days of treatment, the disappearance time of main symptoms and signs, the lung function,and the levels of inflammatory factors in serum in the two groups after treatment were compared,and the clinical effect in the two groups was counted. Results:The total effective rate was 93.7% in the observation group,higher than that of 71.9% in the control group(P<0.05). After treatment,the disappearance time of wheeze,cough,dyspnea and wheezing rale in lung in the observation group was significantly shorter than that in the control group(P<0.01);peak expiratory flow rate(PEFR),forced expiratory volume in one second(FEV1),and forced vital capacity(FVC) in the two groups were significantly increased(P<0.01),and the above indexes of lung function in the observation group were increased more significantly(P<0.01). After treatment,the levels of interleukin-4(IL-4) and eosinophil cationic protein(ECP) in the two groups were significantly decreased(P<0.01), and the levels of Interferon-γ(IFN-γ) were significantly increased(P<0.01);the improvement of the above indexes of inflammatory factors in serum in the observation group was more significant(P<0.01).Conclusion:Bufei Yishen Pingchuan prescription can inhibit inflammatory response of children with persistent asthma with lung-kidney yin deficiency syndrome, and improve lung function of patients, which has significant curative effect on relieving the clinical symptoms of children.
作者
丁珊
方声
李海娇
DING Shan;FANG Sheng;LI Haijiao
出处
《新中医》
CAS
2020年第11期81-84,共4页
New Chinese Medicine
关键词
哮喘持续状态
小儿
肺肾阴虚证
补肺益肾平喘方
炎性因子
肺功能
Persistent asthma
Children
Lung-kidney yin deficiency syndrome
Bufei Yishen Pingchuan prescription
Inflammatory factors
Lung function
