摘要
[目的]分析加减和中散联合头孢克洛咀嚼片对肠系膜淋巴结炎患儿的治疗效果及对消化功能的影响,以期提高肠系膜淋巴结炎患儿的临床治疗效果。[方法]选取2018年4月~2019年4月在我院儿科就诊的肠系膜淋巴结炎的患儿72例作为研究对象,采用随机数字表法将所有患儿分为研究组和对照组,对照组患儿采用头孢克洛咀嚼片治疗,研究组患儿在服用头孢克洛咀嚼片的基础上采用加减和中散进行治疗,观察并统计2组患儿治疗2周后各项临床症状与体征改善情况,统计患儿治疗前后肠系膜淋巴结的横径和纵径,统计患儿治疗中不良反应的发生情况,检测患儿治疗前后血清中胃泌素、胃动素和血管活性肠肽的水平,检测患儿治疗前后粪便中肠杆菌、葡萄球菌、乳杆菌、双歧杆菌水平。[结果]研究组患儿临床疗效治愈比例明显高于对照组(P<0.05),研究组患儿证侯疗效治愈比例高于对照组(P<0.05),而证侯疗效无效的比例低于对照组(P<0.05)。研究组患儿呕吐消失时间、腹痛消失时间、腹胀消失时间、体温水平恢复正常时间均短于对照组(P<0.05),研究组患儿治疗后肠系膜淋巴结横径较治疗前明显减小(P<0.05),2组患儿治疗期间恶心、腹泻及其他不良反应的发生率及不良反应的总发生率均较低,组间差异无统计学意义(P>0.05)。研究组患儿治疗后胃泌素、胃动素、葡萄球菌水平均高于对照组,而乳杆菌、双歧杆菌水平均低于对照组(P<0.05)。[结论]加减和中散联合头孢克洛咀嚼片可以明显提高肠系膜淋巴结炎患儿治疗效果,降低患儿临床症状及体征改善时间,具有较低的不良反应,并且可以提高患儿的消化功能。
[Objective]To analyze the therapeutic effect of addition and subtraction and medium-dispersion cefaclor chewable tablets on children with mesenteric lymphadenitis and the effect on digestive function,in order to improve the clinical treatment effect of children with mesenteric lymphadenitis.[Methods]72 children with mesenteric lymphadenitis who were admitted to our hospital from April 2018 to April 2019 were enrolled.All children were randomly divided into study group and control group. The control group treated with cefaclor chewable tablets,and the study group was treated with addition and subtraction and middle dispersion on the basis of cefaclor chewable tablets.The clinical symptoms and signs were improved after 2 weeks of treatment.The transverse diameter and longitudinal diameter of the mesenteric lymph nodes before and after treatment were counted.The incidence of adverse reactions in the treatment of children was counted.The levels of serum gastrin,motilin and vasoactive intestinal peptide were measured before and after treatment.Levels of Enterobacter,Staphylococcus,Lactobacillus,and Bifidobacteria in feces before and after treatment.[Results]The proportion of clinical curative effect in the study group was significantly higher than that in the study group(P<0.05).The cure rate of the children in the study group was more than the replacement(P<0.05),while the proportion of the ineffective cure syndrome exceeded the average(P<0.05).The disappearance time of vomiting,abdominal pain,abdominal distension and the return of normal body temperature were lower in the study group than those in the control group(P<0.05).The diameter of mesenteric lymph nodes in the study group was significantly lower than that before treatment(P<0.05).The incidence of nausea,diarrhea and other adverse reactions and the total incidence of adverse reactions during the treatment were lower.There was no significant difference between the two groups(P>0.05).The levels of gastrin,motilin and staphylococcus in the study group were higher than those in the control group,while the levels of Lactobacillus and Bifidobacterium were lower than those in the control group(P<0.05).[Conclusion]Addition and subtraction and medium dispersion combined with cefaclor chewable tablets can significantly improve the therapeutic effect of children with mesenteric lymphadenitis,reduce the clinical symptoms and signs of improvement,have lower adverse reactions,and can improve the digestive function of children.
作者
常温来
索恩勇
宋超
谢暕
任晓娜
CHANG Wen-lai;SUO En-yong;SONG Chao;XIE Jian;REN Xiao-na(Department of Pharmacy,Shandong Provincial Third Hospital,Jinan 250000,China)
出处
《中国中西医结合消化杂志》
CAS
2020年第6期449-453,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
肠系膜淋巴结炎
加减和中散
头孢克洛咀嚼片
疗效
消化功能
mesenteric lymphadenitis
addition and subtraction and dispersion
cefaclor chewable tablets
efficacy
digestive function
