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前驱糖尿病与结直肠进展性腺瘤的相关性研究 被引量:3

Relationship between prediabetes and advanced colorectal adenoma
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摘要 前驱糖尿病作为早期2型糖尿病的一个阶段,可能通过多种途径促进肠道细胞增殖,最终诱发肿瘤。本研究纳入结直肠进展性腺瘤患者216例,选取同期结肠镜检查未见结直肠存在异常者628名为健康对照。分析患者的临床资料结果显示,结直肠进展性腺瘤组前驱糖尿病检出率、空腹血糖水平、糖化血红蛋白水平均高于健康对照组[分别为9.3%(20/216)比4.9%(31/628)、(6.3±0.2)mmol/L比(5.4±0.1)mmol/L、(5.8±1.4)%比(5.1±1.2)%],差异均有统计学意义(χ^2=844.000,t=1.156、t=1.531,P均<0.05)。多因素logistic回归分析显示男性、年龄≥50岁、糖化血红蛋白5.7%~6.4%、前驱糖尿病均与结直肠进展性腺瘤有关[OR(95%CI)分别为4.189(2.067~6.231)、3.915(2.243~5.196)、1.126(1.014~1.152)、1.258(1.035~1.616),P均<0.05]。前驱糖尿病是结直肠进展性腺瘤的危险因素,但相关机制复杂,需要进一步研究。
出处 《中华消化杂志》 CAS CSCD 北大核心 2020年第5期342-344,共3页 Chinese Journal of Digestion
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