摘要
下肢动脉腔内治疗是下肢动脉硬化闭塞症患者的常用治疗方法。球囊扩张加支架植入的治疗方式因其再狭窄(ISR)率较高,而不能令人满意。ISR严重影响支架术后患者的预后和生活质量,发生ISR患者往往需要二次手术,但由于费用高、远期通畅效果不佳、支架断裂等一系列问题,预防ISR发生显得尤为重要。舒洛地特对全身血管系统具有广泛的生物学效应,其抗炎、抗血栓、保护血管内皮等作用对防治ISR可能可起到重要作用。笔者就ISR目前诊治的现状及舒洛地特在ISR治疗的应用前景进行综述。
Endovascular treatment of lower extremity arteries is a common treatment method for patients with arteriosclerosis obliterans of the lower extremities.The treatment of balloon dilation plus stent implantation is often unsatisfactory due to its high in-stent restenosis(ISR)rates.ISR seriously affects the prognosis and quality of life of the patients after operation.Patients with ISR usually need a second operation.However,due to a series of problems such as high cost,poor long-term patency rates,and stent fracture,the prevention of ISR is particularly important.Sulodexide has extensive biological effects on cardiovascular system,and its anti-inflammatory,anti-thrombotic,and vascular endothelial protection exerts important beneficial effects on prevention and treatment of ISR.The authors review the current status in diagnosis and treatment of ISR and the application prospects of sulodexide in treatment of ISR.
作者
吉忠杰
张天华
姜维良
JI Zhongjie;ZHANG Tianhua;JIANG Weiliang(Department of Vascular Surgery,the Second Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2020年第6期745-751,共7页
China Journal of General Surgery
基金
吴阶平医学基金会临床科研专项资助基金资助项目(320.6750.19095-5)。
关键词
闭塞性动脉硬化
下肢
血管内操作
移植物闭塞
血管
舒洛地特
综述文献
Arteriosclerosis Obliterans
Lower Extremity
Endovascular Procedures
Graft Occlusion
Vascular
Sulodexide
Review
