摘要
目的将达英-35(炔雌醇环丙孕酮片)与胰岛素增敏剂二甲双胍(Metformin)联合用于多囊卵巢综合征(PCOS)患者的的治疗,总结相关病例资料,探讨该疗法临床价值。方法将2016年1月至2019年1月诊治的PCOS患者作为研究对象,随机分为2组:联合用药组(n=65)采用达英-35+Metformin的治疗方案,对照组(n=68)仅采用达英-35治疗。分析、比较2组患者的临床疗效(包括临床症状缓解、性腺激素水平变化情况以及排卵、妊娠等)情况。结果联合用药组和对照组病例血清LH、FSH和T水平治疗前后比较差异均有统计学意义(P<0.05)。治疗前2组病例血清LH、FSH和T水平比较差异无统计学意义(P>0.05);治疗后联合用药组血清LH[(6.2±1.3)mU/ml vs(8.8±2.4)mUm/L]、FSH[(3.9±1.0)mUm/L vs(5.3±1.4)mU/ml]和T[(2.0±0.7)nmol/L vs(2.8±1.2)nmol/L]水平均低于对照组,差异有统计学意义(均P<0.05)。联合用药组有效率为95.4%,高于对照组的79.4%,差异有统计学意义(P<0.05)。与对照组比较,联合用药组排卵率更高[(84.6%)vs(63.2%)]、妊娠率更高[(44.6%)vs(26.5%)],差异有统计学意义(P<0.05)。结论达英-35联合Metformin治疗PCOS患者血清激素水平变化较单用达英-35改善更加明显,同时联合用药组的临床症状缓解情况更佳,排卵率和妊娠率更高。
Objective To investigate the therapeutic effects of Diane-35(ethinylestradiol and cyproterone tablets)combined with insulin sensitizer on polycystic ovary syndrome(PCOS),and to summarize the clinical data of cases and to explore its clinical application value.Methods The patients with PCOS who were treated were randomly divided into two groups:combined medication group(n=65)and control group(n=68).The patients in combined medication group were treated by Diane-35+metformin,however,the patients in control group were treated by Diane-35 only.The clinical curative effects including clinical symptoms relive,the changes of gonadal hormone levels,and ovulation and pregnancy rate were observed and compared between the two groups.Results There were significant differences in the serum levels of LH,FSH and T in both groups before and after the treatment(P<0.05).Before treatment,there were no significant differences in the serum levels of LH,FSH and T between the two groups(P>0.05).After treatment,the serum levels of LH,FSH and T combined medication group were significant lower than those in control group(P<0.05).The effective rate in combined medication group was 95.4%,which was significant higher than that(79.4%)in control group(P<0.05).Moreover the ovulation rate and pregnancy rate in combined medication group were significant higher than those in control group(P<0.05).Conclusion Diane-35 combined with metformin in treatment of polycystic ovary syndrome can more significantly improve the serum hormone level of patients with PCOS,as compared with simple Diane-35,moreover,Diane-35 combined with metformin can more obviously relieve the clinical symptoms,and improve ovulation rate and pregnancy rate.
作者
苏雅琴
SU Yaqin(The First Hospital of Shijiazhuang City,Hebei,Shijiazhuang 050011,China)
出处
《河北医药》
CAS
2020年第13期2039-2042,共4页
Hebei Medical Journal
