摘要
目的观察吡格列酮联合二甲双胍对依从性差的肥胖型2型糖尿病患者的疗效。方法选择就诊的肥胖型2型糖尿病且有服药经历依从性较差的患者114例,按照随机数字表法分为对照组和研究组,每组57例。2组患者都予以饮食干预,对照组在运动疗法的基础上服用二甲双胍;研究组在运动疗法的基础上联合服用二甲双胍和盐酸吡格列酮。2组患者均连续服用16周,分别检测身体质量指数(BMI)、空腹血糖(FBG)、餐后2 h血糖(2 hBG)、糖化血红蛋白(HbA 1C)、空腹C肽、餐后2 hC肽、血脂、空腹胰岛素(FINS)、餐后2 h胰岛素(2 hINS)、胰岛β细胞功能指数(HOMA-β)及胰岛素抵抗指数(HOMA-IR)等指标。结果2组患者在治疗后的BMI、FBG、2 hBG、HbA 1C、空腹C肽、餐后2 hC肽、血脂、HOMA-IR等指标较治疗前均降低且差异具有统计学意义(P<0.05);FINS、2 hINS、HOMA-β等指标较治疗前上升且差异具有统计学意义(P<0.05)。研究组患者治疗后BMI、FBG、2 hBG、HbA 1C、空腹C肽、餐后2 hC肽、血脂、HOMA-IR,与对照组相比均降低且差异具有统计学意义(P<0.05);研究组治疗后FINS、2 hINS、HOMA-β,与对照组相比上升且差异具有统计学意义(P<0.05)。结论二甲双胍联合吡格列酮治疗能有效控制肥胖型2型糖尿病患者血糖、血脂水平,提高胰岛β细胞功能,降低胰岛素抵抗,二者联合具有协同作用。
Objective To analyze the efficacy of pioglitazone combined with metformin in obese type 2 diabetic patients with poor compliance.Methods A total of 114 patients with obesity type 2 diabetes who had poor medication compliance were selected and divided into the control group and the research group according to the random number table method.The patients in both groups were given dietary intervention.The patients in the control group took metformin on the basis of exercise therapy.The patients in the research group took metformin and pioglitazone hydrochloride on the basis of exercise therapy.The patients in both groups took continuously for 16 weeks.The body mass index(BMI),fasting blood glucose(FBG),postprandial blood glucose(2hBG),glycated hemoglobin(HbA1c),fasting C peptide,postprandial 2h C-peptide,blood lipid,fasting insulin(FINS),and postprandial 2h insulin after meals(2hINS),βcell function index(HOMA-β),and insulin resistance index(HOMA-IR)were measured.Results The BMI,FBG,2hBG,HbA1c,fasting C-peptide,postprandial 2h C-peptide,blood lipid,HOMA-IR and other indexes of the two groups were lower than those before treatment(P<0.05).FINS,2hINS and HOMA-βwere increased compared with the pre-treatment and the difference was statistically significant(P<0.05).After combined treatment,BMI,FBG,2hBG,HbA1c,fasting C-peptide,postprandial 2hC peptide,blood lipid,and HOMA-IR were significantly lower in the study group than in the control group(P<0.05).FINS,2hINS,and HOMA-βwere significantly increased compared with the control group after combined treatment(P<0.05).Conclusion Metformin combined with pioglitazone can effectively control the levels of blood glucose and lipid of patients with obesity type 2 diabetes,improve the function ofβcells and reduce insulin resistance.The combination of the two has a synergistic effect.
作者
狄建宁
虎峻瑞
DI Jianning;HU Junrui(The Third People's Hospital of Yinchuan,Yinchuan 750001,China)
出处
《宁夏医学杂志》
CAS
2020年第6期506-508,共3页
Ningxia Medical Journal
