摘要
慢加急性肝衰竭(acute-on-chronic liver failure,ACLF)是一种以慢性肝病病理损伤为基础,以不同程度肝细胞坏死性病变为特征的病理过程,其具体发生机制尚未完全明确,但各种免疫细胞在其中发挥重要作用已有共识。本文通过阐述临床和动物研究中多种免疫细胞在ACLF发生发展中的变化,了解ACLF免疫学发病机制,以期为临床治疗ACLF提供科学依据。
Acute-on-chronic liver failure(ACLF)is a pathological process characterized by liver cell necrotizing lesions of varying degrees based on the pathological injury of chronic liver disease.Although the specific mechanism is not completely clear,there is a consensus that various immune cells play important roles.In this paper,the changes of various immune cells in the development of ACLF in clinical and animal studies were expounded to understand the pathogenesis of ACLF immunology,so as to provide scientific basis for clinical treatment of ACLF.
作者
李彦霖
杨雪亮
刘小静
吴剑华
王一川
Li Yanlin;Yang Xueliang;Liu Xiaojing;Wu Jianhua;Wang Yichuan(First College of Clinical Medicine,Xi’an Jiaotong University Health Science Center,Xi’an 710061,China;Department of Nutrition,First Hospital Affiliated to Xi’an Jiaotong University,Xi’an 710061,China;Department of Infectious Diseases,First Hospital Affiliated to Xi’an Jiaotong University,Xi’an 710061,China;Second College of Clinical Medicine,Xi’an Jiaotong University Health Science Center,Xi’an 710061,China)
出处
《中国肝脏病杂志（电子版）》
CAS
2020年第2期42-46,共5页
Chinese Journal of Liver Diseases：Electronic Version
基金
陕西省自然科学基础研究计划(2017JM8083)。
关键词
肝功能衰竭
慢加急性
免疫细胞
调控作用
Liver failure,acute-on-chronic
Immune cells
Regulatory effects
