摘要
目的探究高血压病患者中医证候分布特点,找出其与糖脂代谢、颈动脉斑块的相关性。方法采用中医证候问卷的形式对200例原发性高血压患者进行问卷调查,按照《中药新药临床研究指导原则》进行证候判定;采用葡萄糖氧化酶法(GOD)检测患者空腹血糖(GLU),采用酶法检测患者总胆固醇(TC)、甘油三脂(TG),采用抑制法检测低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C);采用彩超多普勒超声检测患者颈动脉内中膜厚度(IMT)。结果200例高血压患者证候分布痰湿壅盛证最为常见;阴虚阳亢证高血压患者空腹血糖水平最高;痰湿壅盛证高血压患者TC、LDL-C水平最高;痰湿壅盛证高血压患者颈动脉斑块阳性率最高。结论高血压病患者证候分布以痰湿壅盛证最为常见,阴虚阳亢证高血压患者最易合并糖代谢紊乱,痰湿壅盛证高血压患者最易合并脂质代谢紊乱,痰湿壅盛证高血压患者易合并动脉粥样硬化性疾病,为早期预防高血压病合并糖脂代谢及靶器官损害提供理论依据。
Objective To explore the characteristics of TCM syndrome distribution in patients with hypertension,and to find out the correlation between TCM syndrome and carbohydrate metabolism,carotid plaque.Methods 200 patients with essential hypertension were investigated with TCM syndrome questionnaire,and the syndrome was determined according to the guiding principle of clinical research of new Chinese medicine;Fasting blood glucose(Glu)was measured by glucose oxidase(God),total cholesterol(TC)and triglyceride(TG)were measured by enzyme method,low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)were detected by inhibition method.Carotid plaques were detected by color Doppler ultrasound.Results In 200 cases of hypertension,excessive phlegm-dampness syndrome was the highest.The fasting blood glucose level of hypertension patients with yin deficiency yang hyperactivity syndrome was the highes.The level of TC and LDL-C was the highest in patients with hypertension of excessive phlegm-dampness syndrome.The positive rate of carotid plaque was the highest in the patients with hypertension of excessive phlegm-dampness syndrome.Conclusion Excessive phlegm-dampness syndrome is the most common syndrome in the distribution of hypertension,yin deficiency yang hyperactivity syndrome is the most likely to be associated with glucose metabolism disorder,excessive phlegm-dampness syndrome is the most likely to be associated with lipid metabolism disorder,and excessive phlegm-dampness syndrome is the most likely to be associated with atherosclerotic diseases,providing theoretical basis for the early prevention of hypertension combined with glycolipid metabolism and target organ damage.
作者
杨金果
汤献文
严权浩
YANG Jinguo;TANG Xianwen;YAN Quanhao(Department of Cardiology,Shenzhen Hospital of Beijing University of Chinese Medicine(Longgang),Guangdong Province,Shenzhen 518000,China)
出处
《中国中医药现代远程教育》
2020年第11期52-55,共4页
Chinese Medicine Modern Distance Education of China
基金
深圳市龙岗区医疗卫生科技计划项目【No.LGKCYLWS2018000018】。
关键词
高血压病
中医证候
糖脂代谢
颈动脉斑块
眩晕
hypertension
TCM syndrome
glycolipid metabolism
carotid plaque
vertigo
