摘要
目的:观察二仙汤合玉屏风散加味治疗肾阳虚证排卵障碍性不孕的临床疗效。方法:选取符合纳入标准的肾阳虚证排卵障碍性不孕患者60例,签署知情同意书,按随机数字表法分为试验组和对照组各30例,其中对照组予以克罗米芬胶囊治疗,自经期第5日开始口服克罗米芬胶囊,连服5日后停药为一疗程,连服三个疗程,试验组予以二仙汤合玉屏风散加味+中药保留灌肠治疗,于经净后3天开始服药及灌肠,直至月经来潮为一疗程,连续治疗三个疗程,比较两组的临床疗效、中医证候、卵泡发育、排卵及子宫内膜厚度情况及机体卵泡刺激素、黄体生成素、雌激素水平变化情况。结果:两组治疗后在临床疗效、中医证候疗效、两组卵泡发育情况及排卵期机体激素水平较治疗前改善明显,试验组优于对照组,差异有统计学意义(P<0.05);安全性指标在治疗前后未见明显变化,不具有统计学差异(P>0.05)。结论:二仙汤合玉屏风散加味治疗肾阳虚证排卵障碍性不孕临床疗效显著,较西药组效果明显,可显著改善肾阳虚证排卵障碍性不孕患者的临床症状、促进优势卵泡发育及排卵,改善机体卵泡刺激素、黄体生成素以及雌激素水平,增加受孕成功机率。
objective:to observe the clinical effect of Erxian Tang and Yupingfeng San(二仙汤合玉屏风散EXTAYPFS)in the treatment of Shen Yang Deficiency Syndrome with ovulatory dysfunction infertility.Methods:Selection into the standard of 60 patients with Shen Yang Deficiency Syndrome ovulation obstructive infertility,signed informed consent,according to random number table method is divided into experimental group and control group,30 cases of control group to give Clomifene Citrate capsule treatment,oral g since period 5 days,even served 5 withdrawal for a period of treatment in the future,even served three treatment,treatment group shall be EXTAYPFS flavored+Chinese Medicine retention enema treatment,3 days after the net began to take medicine and enema,until the menstrual period for a period of treatment,treatment of three consecutive period of treatment,The clinical efficacy,TCM syndromes,follicular development and changes of follicular stimulating hormone,luteinizing hormone and estrogen levels in the two groups were compared.Results:after treatment,the clinical efficacy,TCM syndrome efficacy,follicular development and ovulation hormone level of the two groups were significantly improved compared with that before treatment,and the experimental group was better than the control group,with statistically significant differences(P<0.05).There was no significant change in safety index before and after treatment,and there was no statistical difference(P>0.05).Conclusion:EXTAYPFS flavored treatment of Shen Yang Deficiency syndrome ovulation obstructive infertility clinical curative effect is distinct,the western medicine group effect is obvious,can significantly improve the clinical symptoms of patients with kidney Yang deficiency syndrome ovulation obstructive infertility,promote the follicular development and ovulation,improve the body’s follicle-stimulating hormone,luteinizing hormone and estrogen levels,increase fertility success probability.
作者
徐文彬
王文鹏
祁鹏
杜志斌
刘琼辉
XU Wenbin;WANG Wenpeng;QI peng;DU Zhibin;LIU Qionghui(Hunan University of Chinese Medical College postgraduate,Hunan,Changsha 410208,China;Traditional Chinese Medicine Hospital,Chongqing 408300,China)
出处
《中医药临床杂志》
2020年第6期1151-1155,共5页
Clinical Journal of Traditional Chinese Medicine
基金
重庆市垫江县科技项目基金(djkjzdxm2018jsyfysfyy020)。
关键词
二仙汤合玉屏风散加味
肾阳虚证
排卵障碍
不孕
Erxian Tang
Yupingfeng San
ShenYang Deficiency Syndrome
Ovulatory disorders
infertility
