摘要
目的分析阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者认知功能的损害情况。方法选取2017年11月~2019年3月石家庄市第一医院172例因打鼾行多导睡眠图监测的OSAHS患者,按睡眠呼吸暂停低通气指数(AHI)将患者分为轻度组(47例)、中度组(39例)、重度组(51例)和鼾症(单纯鼾症)组(35例),比较各组患者睡眠参数、睡眠结构参数、颅脑MRI检查结果和认知功能测试结果。结果轻度组、中度组与重度组AHI、氧减指数(ODI)和呼吸相关微觉醒指数(RI)均高于鼾症组,且组间比较差异有统计学意义(P <0.05)。各组间3期睡眠、总睡眠时间和快速动眼期(REM)睡眠比较差异均无统计学意义(P> 0.05)。重度组脉氧饱和度低于90%的时间占总睡眠时间的百分比(TS90%)高于鼾症组、轻度组和中度组,最低脉氧饱和度(LSaO_2)与平均脉氧饱和度(MSaO_2)均低于鼾症组、轻度组和中度组,差异有统计学意义(P <0.05)。轻度组、中度组和重度组MoCA评分均低于鼾症组,且随病情加重MoCA评分降低,组间比较差异均有统计学意义(P <0.05)。其中中度组延迟记忆评分低于鼾症组,重度组延迟记忆评分和空间与执行评分低于鼾症组、轻度组和中度组,差异有统计学意义(P <0.05)。重度组海马萎缩评分高于鼾症组、轻度组和中度组,中度组与重度组侧脑室周围高信号灶(PVH)评分高于鼾症组及轻度组,差异均有统计学意义(P <0.05)。结论 OSAHS患者认知功能损害主要表现在延迟记忆、空间与执行方面,其中以重度患者损害最为显著,且伴有相应颅内结构受累。
Objective To analyze the cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome.Methods 172 patients with snoring who were monitored by polysomnography were divided into mild group,moderate group,severe group and snoring group according to sleep apnea hypopnea index(AHI),the sleep parameters,brain MRI and cognitive function of each group were compared.Results AHI,ODI and RI of mild group,moderate group and severe group were higher than those of the snoring group,and the difference between the two groups was statistically significant(P<0.05).TS90%of severe group was higher than that of snoring group,mild group and moderate group,lsao2 and MSaO2 were lower than that of snoring group,mild group and moderate group,the difference was statistically significant(P<0.05).The MOCA scores of mild group,moderate group and severe group were lower than those of the snoring group,and the MOCA scores decreased with the aggravation of the disease,the difference between the two groups was statistically significant(P<0.05).The scores of delayed memory in the moderate group were lower than those in the snoring group,and the scores of delayed memory,space and execution in the severe group were lower than those in the snoring group,the mild group and the moderate group(P<0.05).The scores of hippocampal atrophy in the severe group were higher than those in the snoring group,the mild group and the moderate group,and the PVH scores in the moderate group and the severe group were higher than those in the snoring group and the mild group(P<0.05).Conclusion The cognitive impairment in patients with obstructive sleep apnea syndrome is mainly manifested in delayed memory,space and execution,especially in severe patients,with the corresponding intracranial structure involved.
作者
宋哲
鲍莎莎
孟丽
Song Zhe;Bao Shasha;Meng Li(Department of Neurology,The First Hospital of Shijiazhuang,Shijiazhuang 050000,China)
出处
《中华保健医学杂志》
2020年第3期137-139,共3页
Chinese Journal of Health Care and Medicine
基金
石家庄市科学技术研究与发展指导计划(161462503)。
