摘要
沙门菌效应蛋白能够调控宿主的炎症反应,重排宿主的细胞骨架,促进细菌的侵入和复制,并逃避宿主的免疫监视。效应蛋白通过Ⅲ型分泌系统转运到宿主内膜系统和细胞质中,不同的效应蛋白在沙门菌致病的各个阶段发挥不同的作用。文章对沙门菌在感染宿主过程中相关T3SS效应蛋白发挥的功能进行了综述,以期为沙门菌致病机制研究和疫苗研制提供参考。
Salmonella effector proteins can regulate the host′s inflammatory response,rearrange the host′s cytoskeleton,promote bacterial invasion and replication,and evade host immune surveillance.Effector proteins are transported into the host′s endometrial system and cytoplasm through the typeⅢsecretion system,and different effector proteins play different roles in various stages of Salmonella pathogenesis.This paper reviewed the function of Salmonella related T3 SS effector proteins during host infection to provide a reference for the research of pathogenic mechanism of Salmonella and Salmonellosis vaccine development.
作者
王超
康喜龙
顾丹
孟闯
焦新安
潘志明
WANG Chao;KANG Xilong;GU Dan;MENG Chuang;JIAO Xin′an;PAN Zhiming(Jiangsu Key Laboratory of Zoonosis,Yangzhou University,Yangzhou,Jiangsu 225009;Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonosis,Yangzhou University,Yangzhou,Jiangsu 225009;Key Laboratory of Prevention and Control of Biological Hazard Factors(Animal Origin)for Agrifood Safety and Quality,Ministry of Agriculture,Yangzhou University,Yangzhou,Jiangsu 225009;J4o.int International Research Laboratory of Agriculture and Agri-product Safety of the Ministry of Education,Yangzhou University,Yangzhou,Jiangsu 225009)
出处
《中国家禽》
北大核心
2020年第6期83-88,共6页
China Poultry
基金
国家重点研发计划项目(2016YFD0501607)
国家自然科学基金重点项目(31730094)
扬州大学科技创新团队(2016)
江苏省重点研发计划(BE2018334)
江苏省高校优势学科建设工程资助项目(PAPD)。
关键词
沙门菌
Ⅲ型分泌系统
效应蛋白
功能
Salmonella
typeⅢsecretion system
effector protein
function
