摘要
目的系统评价单纯复方中药治疗小儿积滞的有效性及安全性。方法以"积滞""中医药""dyspepsia"等为主题词,检索PubMed、Cochrane图书馆、CNKI、维普、CBM、万方,筛选文献后提取资料,应用ROB偏倚风险评估表评价纳入文献质量,应用RevMan5.3、Stata15进行Meta分析。结果①临床总有效率中药优于西药[OR=2.51,95%CI(1.75,3.59),P<0.05],但逊于外治法[OR=0.21,95%CI(0.12,0.37),P<0.05];进行有序分类数据的Meta分析时,结果提示中药对比西药或中医外治法并无显著提高其治愈程度;②中药治疗后小儿积滞食欲改善积分更优[WMD=0.59, 95%CI(0.40,0.78),P<0.05],其余积分指标Meta分析中,中药对比西药或中医外治法并无明显优势。结论复方中药治疗小儿积滞总有效率逊于中医外治法而优于西药,且相较于其他疗法,中药治疗在改善患儿食欲方面具有明显优势。
Objective To evaluate the efficacy and safety of therapy of compound Chinese medicine in infantile dyspepsia.Methods The following keywords were used:dyspepsia,Stagnation,Chinese medicine,etc.Literatures were searched from Pubmed,Cochrane Library,CNKI,VIP,CBM and Wanfang Database.After studies being selected,the data of them was extracted.ROB assessment was utilized to evaluate the quality of eligible studies and Meta-analysis was performed with RevMan5.3 and Stata15.Results①The result of Meta-analysis demonstrated that a more superior total effective rate of TCM group was observed when compared with western medicine group in the treatment of infantile dyspepsia[OR=2.51,95%CI(1.75,3.59),P<0.05],but not more superior than that of external therapies group[OR=0.21,95%CI(0.12,0.37),P<0.05].When utilizing the meta-analysis of ordinal categorical variable,there was no significant enhancement of the effect degree between the group with the therapy of compound Chinese medicine and the group not with it.②Compound Chinese medicine was more superior than other therapies in reducing the clinical symptom score of appetite[WMD=0.59,95%CI(0.40,0.78),P<0.05],but it was not remarkably superior for the aspect of other score.Conclusion The therapy of compound Chinese medicine shows a lower total percentage of effectiveness than external therapies,but higher than western medicine.Compared with other therapies,compound Chinese medicine appears to reduce the clinical symptom total score of appetite.
作者
邹小秋
吉训超
黄晓华
欧阳学认
ZOU Xiaoqiu;JI Xunchao;HUANG Xiaohua;OUYANG Xueren(Guangzhou University of Chinese Medicine,Guangzhou 510405,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China)
出处
《云南中医学院学报》
2020年第1期19-25,共7页
Journal of Yunnan University of Traditional Chinese Medicine
基金
广东省中医药局课题(20171087)。
关键词
复方中药
中医外治法
小儿积滞
META分析
随机对照试验
compound Chinese medicine
external therapies
infantile dyspepsia
Meta-analysis
randomized controlled trials
