摘要
目的:观察复方蛋氨酸胆碱片治疗非酒精性脂肪性肝病(简称脂肪肝)的疗效及安全性。方法:随机纳入我院2016年3月至2018年12月期间诊治的脂肪肝患者80例,按治疗药物不同分对照组(40例接受多烯磷脂酰胆碱胶囊治疗)和研究组(40例接受复方蛋氨酸胆碱片治疗),比较治疗效果、不良反应等。结果:研究组治疗有效率95%高于对照组75%(P<0.05)。治疗前组在肝功能指标、血脂,治疗后研究组GGT、AST、ALT低于对照组(P<0.05)。治疗前组间肝功能指标差异无统计学意义(P>0.05),治疗后,研究组TG、TC低于对照组(P<0.05)。研究组不良反应总发生率5%低于对照组7.50%,差异不具有统计学意义(P>0.05)。结论:临床治疗脂肪肝可给予复方蛋氨酸胆碱片治疗,可显著改善患者肝功能,安全高效。
Objective:To observe the efficacy and safety of compound methionine choline tablets in the treatment of non-alcoholic fatty liver disease.Methods:80 patients with fatty liver were randomly included in our hospital from March 2016 to December 2018.They were divided into control group(40 patients were treated with polyene phosphatidylcholine capsule)and study group(40 patients were treated with compound methionine choline tablet)according to different therapeutic drugs.The therapeutic effects and adverse reactions were compared.Results:The effective rate of the study group was 95%higher than that of the control group(P<0.05).After treatment,GGT,AST and ALT in the study group were lower than those in the control group(P<0.05).Before treatment,there was little difference in liver function between the two groups(P>0.05).After treatment,TG and TC in the study group were lower than those in the control group(P<0.05).The total incidence of adverse reactions in the study group was 5%lower than that in the control group(7.50%)(P>0.05).Conclusion:The clinical treatment of fatty liver can be given compound methionine choline tablets can significantly improve the liver function of patients,safe and efficient.
作者
张昊
谢甲贝
ZHANG Hao;XIE Jia-be(Department of Gastroenterology,Henan people's Hospital(Zhengzhou University People's Hospital),Zhengzhou Henan 450000,China)
出处
《药品评价》
CAS
2020年第5期37-39,共3页
Drug Evaluation
关键词
脂肪肝
复方蛋氨酸胆碱片
多烯磷脂酰胆碱胶囊
肝功能
Fatty Liver
Compound Methionine Choline Tablet
Polyene Phosphatidylcholine Capsule
Liver Function
