摘要
目的:研究戊酸雌二醇、醋酸甲羟孕酮联合补肾活血汤治疗低促性腺激素性闭经合并不孕症的临床疗效。方法:选取本院2018年6月至2019年6月收纳的低促性腺素性闭经合并不孕症患者90例,按照入院先后顺序将其分为观察组与对照组各45例,对照组采取戊酸雌二醇、醋酸甲羟孕酮治疗,观察组在此基础上增加补肾活血汤,进行比较。结果:治疗前,两组患者血清卵泡刺激素(FSH)、黄体生成素(LH)和雌二醇(E2)水平经比较差异无统计学意义(P>0.05),治疗后,两组患者血清FSH和LH水平明显下降、E2明显上升,差异有统计学意义(P<0.05),观察组患者血清FSH和LH水平显著低于对照组患者,E2水平显著高于对照组患者,差异有统计学意义(P<0.05);治疗前,两组患者子宫体积、卵巢体积和子宫内膜厚度经比较差异无统计学意义(P>0.05),治疗后,两组患者子宫体积、卵巢体积和子宫内膜厚度均有所上升,差异有统计学意义(P<0.05),观察组患者子宫体积、卵巢体积和子宫内膜厚度比对照组患者要高,差异有统计学意义(P<0.05);观察组临床疗效总有效率为95.56%,对照组患者临床疗效总有效率为82.00%,观察组患者临床疗效总有效率显著高于对照组患者,差异有统计学意义(P<0.05);观察组有30名患者成功妊娠,占总人数的66.67%,对照组有20名患者成功妊娠,占总人数的44.44%,观察组妊娠成功人数要高于对照组,差异有统计学意义(P<0.05)。结论:运用戊酸雌二醇、醋酸甲羟孕酮联合补肾活血汤治疗低促性腺激素性闭经合并不孕症能够有效改善患者闭经症状,加强卵巢储备功能,提高患者妊娠几率。
Objective:To study the clinical effect of estradiol valerate,medroxyprogesterone acetate and Bushen Huoxue Decoction in the treatment of hypogonadotropic amenorrhea with infertility.Methods:90 patients with hypogonadotropic amenorrhea and infertility admitted in our hospital from June 2018 to June 2019 were divided into observation group and control group according to the sequence of admission.The control group was treated with estradiol valerate and medroxyprogesterone acetate.On this basis,the observation group added Bushen Huoxue Decoction for comparison.Results:Before treatment,there was no significant difference between the two groups in serum FSH,LH and E2 levels(P>0.05).After treatment,the serum FSH and LH levels of the two groups were significantly decreased,and E Е was significantly increased(P<0.05).The serum FSH and LH levels of the observation group were significantly lower than those of the control group,and E Е levels were significantly higher than those of the control group Before treatment,there was no significant difference in the volume of uterus,ovary and endometrial thickness between the two groups(P>0.05).After treatment,the volume of uterus,ovary and endometrial thickness of the two groups increased,the difference was statistically significant(P<0.05).The comparison of the volume of uterus,ovary and endometrial thickness of the observation group was statistically significant(P<0.05)The difference was statistically significant(P<0.05);the total effective rate of the observation group was 95.56%,the total effective rate of the control group was 82.00%,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05);30 patients in the observation group were pregnant successfully,accounting for 66.67%,and 20 in the control group The number of successful pregnancies in the observation group was significantly higher than that in the control group(P<0.05).Conclusion:Using estradiol valerate,medroxyprogesterone acetate and Bushen Huoxue Decoction to treat low gonadotropin amenorrhea combined with infertility can effectively improve the symptoms of amenorrhea,strengthen the ovarian reserve function,and improve the pregnancy rate of patients.
作者
段语
DUAN Yu(Department of Gynecology and Obstetrics,Fenyi County People's Hospital,Xinyu Jiangxi 336600,China)
出处
《药品评价》
CAS
2020年第6期46-48,共3页
Drug Evaluation
关键词
补肾活血汤
不孕症
低促性腺激素性闭经
戊酸雌二醇
Bushen Huoxue Decoction
Infertility
Hypogonadotropic Amenorrhea
Estradiol Valerate
