摘要
目的探讨纳洛酮联合更昔洛韦对小儿病毒性脑炎患儿神经功能及炎症细胞因子水平的影响。方法将2016年7月至2018年12月平顶山市第一人民医院收治的97例病毒性脑炎患儿分为观察组(n=49)和对照组(n=48);对照组患儿给予更昔洛韦治疗,观察组患儿给予纳洛酮联合更昔洛韦治疗,疗程均为14 d。记录2组患儿体温正常时间、头痛缓解时间、惊厥消失时间以及意识恢复时间,比较治疗前后2组患儿血清神经元特异性烯醇化酶(NSE)、钙结合蛋白(S-100β蛋白)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)和IL-6水平。结果观察组患儿体温正常时间、头痛缓解时间、惊厥消失时间及意识恢复时间均短于对照组(P <0.05)。治疗前2组患儿血清NSE、S-100β蛋白、TNF-α、IL-1β和IL-6水平比较差异无统计学意义(P> 0.05);治疗后2组患儿血清NSE、S-100β蛋白、TNF-α、IL-1β和IL-6水平低于治疗前(P <0.05),且观察组患儿血清NSE、S-100β蛋白、TNF-α、IL-1β和IL-6水平低于对照组(P <0.05)。结论纳洛酮联合更昔洛韦可有效改善病毒性脑炎患儿神经功能和炎症细胞因子水平,促进其临床症状和体征的恢复,提高临床效果。
Objective To investigate the effects of naloxone combined with ganciclovir on neurological function and inflammatory cytokines levels in children with viral encephalitis.Methods A total of 97 children with viral encephalitis admitted to the First People′s Hospital of Pingdingshan City from July 2016 to December 2018 were randomly divided into observation group(n=49)and control group(n=48).The children in the control group were treated with ganciclovir,and the children in the observation group were treated with naloxone combined with ganciclovir.The course of treatment was 14 days.The normal temperature recovery time,headache relief time,convulsion disappearance time and consciousness recovery time of the children in the two groups were recorded.The serum levels of neuron-specific enolase(NSE),calcium binding protein(S-100β),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)and interleukin-6(IL-6)of the two groups were compared before and after treatment.Results The normal temperature recovery time,headache relief time,convulsion disappearance time and consciousness recovery time of the children in the observation group was shorter than that in the control group(P<0.05).There was no significant difference in the serum levels of NSE,S-100β,TNF-α,IL-1βand IL-6 between the two groups before treatment(P>0.05).After treatment,the serum levels of NSE,S-100β,TNF-α,IL-1βand IL-6 in the two groups were lower than those before treatment(P<0.05),and the serum levels of NSE,S-100β,TNF-α,IL-1βand IL-6 in the observation group were lower than those in the control group(P<0.05).Conclusion The treatment of naloxone combined with ganciclovir can effectively improve neurological function and reduce the inflammatory cytokine levels in children with viral encephalitis,and it also can promote the recovery of clinical symptoms,and improve the clinical effects.
作者
刘利利
LIU Lili(Department of Pediatrics,the First People′s Hospital of Pingdingshan City,Pingdingshan 467000,Henan Province,China)
出处
《新乡医学院学报》
CAS
2020年第6期552-554,共3页
Journal of Xinxiang Medical University
