摘要
目的分析溴莫尼定噻吗洛尔滴眼液治疗原发性开角型青光眼患者的疗效与安全性。方法回顾性分析2015年1月至2018年1月于我院进行治疗的128例原发性开角型青光眼患者为研究对象,根据患者治疗方法分为A组45例(溴莫尼定噻吗洛尔滴眼液)治疗、B组42例(溴莫尼定滴眼液)和C组41例(噻吗洛尔滴眼液),对比3组患者治疗后总有效率、眼内压、眼内血流动力学指标、眼内病理变化和不良反应。结果治疗后6个月A组患者的总有效率明显高于B组(χ^2=4.240,P=0.039)和C组(χ^2=7.964,P<0.01),但B组和C组间差异无统计学意义(P>0.05);治疗6个月后3组患者的眼内压均低于治疗前,A组治疗后眼内压明显低于B组(t=-2.270,P=0.026)和C组(t=-2.368,P=0.020),B组和C组间差异无统计学意义(P>0.05);治疗后6个月A组患者阻力指数小于治疗前,且明显小于B组(t=-5.167,P<0.01)和C组(t=-4.632,P<0.01),但B组和C组组间、组内对比差异无统计学意义(P>0.05);治疗后6个月A组患者视网膜神经纤维层厚度厚于治疗前,且明显厚于B组(t=2.289,P=0.025)和C组(t=2.313,P=0.023),但B组和C组组间、组内对比差异无统计学意义(P>0.05);治疗后6个月A组患者的不良反应发生率低于B组(χ^2=3.981,P=0.046)和C组(χ^2=7.611,P=0.006),但B组和C间差异无统计学意义(P>0.05)。结论溴莫尼定噻吗洛尔滴眼液用于治疗原发性开角型青光眼能够显著降低眼内压,改善眼部的血流动力学,具有保护视神经,降低不良反应的作用,安全有效。
Objective To investigate the efficacy and safety of brimonidine/timolol eye drops in patients with primary open-angle glaucoma.Methods A retrospective analysis was performed of 128 patients with primary open-angle glaucoma treated in our hospital between January 2015 and January 2018.Based on the medications,the subjects were divided into group A(n=45,given brimonidine/timolol eye drops),group B(n=42,given brimonidine eye drops),and group C(n=41,given timolol eye drops).After the treatment,the three groups were compared for total response rate,intraocular pressure,intraocular hemodynamics,intraocular pathology and adverse reactions.Results At six months of treatment,the overall treatment response in group A was significantly higher than that in group B(χ^2=4.240,P=0.039)and group C(χ^2=7.964,P<0.01),but did not differ statistically between groups B and C(P>0.05).After six months of treatment,the intraocular pressure level in any of the three groups was lower than baseline,and was significantly lower in group A than that in group B(t=-2.270,P=0.026)or group C(t=-2.368,P=0.020),but did not differ statistically between groups B and C(P>0.05).At six months of treatment,the vascular resistance index in group A was lowered compared with baseline,and was also significantly lower than that in group B(t=-5.167,P<0.01)or group C(t=-4.632,P<0.01),but the vascular resistance index did not statistically significant differ within or between groups B and C(P>0.05).At six months of treatment,the retinal nerve fiber layer in group A was thicker compared with baseline,and was also significantly thicker than that in group B(t=2.289,P=0.025)or group C(t=2.313,P=0.023),but the thickness of retinal nerve fiber layer did not statistically significant differ within or between groups B and C(P>0.05).At six months of treatment,the incidence of adverse reactions in group A was lower than that in group B(χ^2=3.981,P=0.046)or group C(χ^2=7.611,P=0.006),but did not differ statistically between groups B and C(P>0.05).Conclusion Brimonidine/timolol eye drops used for treatment of primary open-angle glaucoma can significantly reduce intraocular pressure,improve intraocular hemodynamics and protect the optic nerve,with fewer adverse reactions and good efficacy.
作者
梁萍英
刘君
张丽红
Liang Pingying;Liu Jun;Zhang Lihong(Department of Ophthalmology,Changzhi People′s Hospital Affiliated to Shanxi Medical University,Shanxi 046000,China)
出处
《中国药物与临床》
CAS
2020年第12期1936-1939,共4页
Chinese Remedies & Clinics
