摘要
目的探讨多囊卵巢综合征(PCOS)患者血清部分必需元素水平变化及其与胰岛素抵抗(IR)的关系。方法选取PCOS患者85例(PCOS组)和同期参加体检的健康育龄期女性90例(对照组),检测其空腹血糖(FPG)、空腹胰岛素(FINS)及血清铜、锌、镁、铁、钙5种必需元素水平,计算胰岛素抵抗指数(HOMA-IR),再根据HOMA-IR将PCOS患者进一步分为IR组(40例)和非IR组(45例),比较分析各组上述指标的差异。采用logistic回归分析评估PCOS患者发生IR的影响因素。结果PCOS患者FINS、HOMA-IR及血清铜水平明显高于对照组,血清锌、镁水平明显低于对照组(P<0.05),而血清铁和钙与对照组比较差异无统计学意义(P>0.05)。在PCOS患者中,IR组的BMI、FPG、FINS、HOMA-IR及血清铜水平明显高于非IR组,血清锌水平明显低于非IR组(P<0.05),而血清镁、铁及钙水平比较差异无统计学意义(P>0.05)。Logistic回归分析结果显示,BMI、FPG和血清铜水平升高及血清锌水平降低为PCOS患者发生IR的独立危险因素(P<0.05)。结论必需元素分布不均及代谢紊乱可能参与PCOS的发生、发展,铜和锌元素可能参与了PCOS患者IR的发生。
Objective To investigate the changes of serum necessary elements levels in patients with polycystic ovary syndrome(PCOS)and its relationship with insulin resistance(IR).Methods Eighty-five patients with PCOS(PCOS group)and 90 healthy women of childbearing age who participated in the physical examination(control group)at the same time were selected to detect fasting plasma glucose(FPG),fasting insulin(FINS)and serum copper,zinc,magnesium,iron,calcium levels,calculate the insulin resistance index(HOMA-IR).PCOS patients were divided into IR group(40 cases)and non-IR group(45 cases)according to the HOMA-IR,then to compare and analyze the differences of the above indicators in each group.Logistic regression analysis was used to evaluate the influencing factors of IR in PCOS patients.Results FINS,HOMA-IR and serum copper level of PCOS patients were significantly higher than those of the control group,while the serum zinc and magnesium levels were significantly lower than those of the control group(P<0.05).However,there were no statistically significant differences in serum iron and calcium compared with the control group(P>0.05).Among PCOS patients,BMI,FPG,FINS,HOMA-IR and serum copper levels in the IR group were significantly higher than those in the non-IR group,and the serum zinc levels were significantly lower than those in the non-IR group(P<0.05),while serum magnesium,iron and calcium levels were not statistically different(P>0.05).Logistic regression analysis showed that increased BMI,FPG and serum copper levels and decreased serum zinc level were independent risk factors for IR in PCOS patients(P<0.05).Conclusion The uneven distribution of necessary elements and metabolic disorders may be involved in the development and progression of PCOS.Copper and zinc may be involved in the occurrence of IR in patients with PCOS.
作者
肖玲
杨颖
雷婷
Xiao Ling;Yang Ying;Lei Ting(Department of Gynecology,Xiangyang Maternal and Child Health Hospital,Xiangyang 441021,China;不详)
出处
《临床内科杂志》
CAS
2020年第5期339-341,共3页
Journal of Clinical Internal Medicine
关键词
多囊卵巢综合征
必需元素
胰岛素抵抗
铜
锌
Polycystic ovary syndrome
Necessary elements
Insulin resistance
Copper
Zinc
