摘要
为了明确流体剪切力对牙周膜细胞的作用以及为后续相关研究提供理论依据,通过查阅文献发现流体剪切力可通过miRNA-132/PI3K/mTOR信号通路、ERK/p38/JNK MAPK信号通路和Wnt/LEF-1信号通路促进牙周膜细胞成骨分化,此外,还可调控牙周膜细胞的增殖,抑制细胞的迁移,还可影响炎症因子COX-2的表达。未来可进一步研究流体剪切力对牙周膜细胞确切的增殖效应及其具体机制。
The study aims to clarify the effects of fluid shear stress on periodontal ligament cells and provide a theoretical basis for subsequent related researches.By reviewing the related literatures,it is revealed that fluid shear stress can promote the osteogenic differentiation of periodontal ligament cells via miRNA-132/PI3K/mTOR signaling pathway,ERK/p38/JNK MAPK signaling pathway andWnt/LEF-1 signaling pathway.In addition,fluid shear stress can also regulate the proliferation of periodontal ligament cells,inhibit cell migration,and affect the expression of inflammatory factor COX-2.In the future,the exact proliferation effect of fluid shear stress on periodontal ligament cells and its specific mechanism can be further studied.
作者
马成华
张宇
景鹏举
李培武
MA Chenghua;ZHANG Yu;JING Pengju;LI Peiwu(Emergency Center,Lanzhou University Second Hospital,Lanzhou 730000,China)
出处
《中国医学物理学杂志》
CSCD
2020年第7期908-911,共4页
Chinese Journal of Medical Physics
基金
国家自然科学基金(81672207)。
关键词
流体剪切力
牙周膜细胞
信号通路
细胞增殖
细胞分化
综述
fluid shear stress
periodontal ligament cell
signaling pathway
cell proliferation
cell differentiation
review
