摘要
天然免疫通过模式识别受体(PRRs)识别侵入宿主机体的病原相关分子模式(PAMPs)。DNA受体主要识别病原DNA,并通过接头蛋白MyD88和STING诱导产生Ⅰ型干扰素或炎性因子抵御病原入侵。近年来,DNA病原对我国畜牧养殖业产生了巨大威胁,天然免疫DNA受体在抗动物疫病方面的研究逐渐成为热点。本文将重点介绍TLR9、DAI、DDX41、AIM2、IFI16、cGAS等常见DNA感受器的信号通路及其在畜禽抗感染免疫中的研究进展。
Innate immune system detects foreign pathogen associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs).Upon recognition of DNA,the DNA sensors recruit adaptor MyD88 or STING to induce downstream type Ι interferons and inflammatory cytokines to defense the infections.DNA pathogens have posed a great threat to Chinese animal husbandry industry in recent years and the effect of innate immune DNA receptors on anti-infection has become a hot research topic.This review focuses on the signal pathways and research progress of TLR9,DAI,DDX41,AIM2,IFI16,cGAS and other common cytosolic/nuclear DNA receptors in the anti-infection innate immunity of livestock and poultry.
作者
杨洁
季星妤
朱媛媛
朱建中
YANG Jie;JI Xing-yu;ZHU Yuan-yuan;ZHU Jian-zhong(College Veterinary Medicine,Yangzhou University,Yangzhou 225009,China;Comparative Medicine Research Institute,Yangzhou University,Yangzhou 225009,China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou 225009,China;Joint International Research Laboratory of Agriculture and Agri-Product Safety,Yangzhou 225009,China)
出处
《中国动物传染病学报》
CAS
北大核心
2020年第4期103-111,共9页
Chinese Journal of Animal Infectious Diseases
基金
国家重点研发项目(2017YFD0502301)
国家自然科学基金项目(31672523,31872450)
江苏高校优势学科建设工程资助项目(PAPD)。
