摘要
冠心病(CHD)是一种复杂的多因素疾病,正确识别CHD相关的危险因素、构建CHD风险预测模型是预防和控制心血管病的必要前提.目前国内外已有诸多CHD风险预测模型,但仍存在局限性从而影响了模型的临床适用性.近年来提出了联合危险因子与易感基因构建CHD风险评估模型的新策略,但其对于评估效能的提升作用仍存在争议.本文简要概述国内外CHD风险评估模型研究进展,分析风险评估模型存在的局限性,探讨新危险因子联合易感基因的新策略对CHD评估效能的提升作用.
Coronary heart disease(CHD)is a complex multifactorial disease.It is necessary to correctly identify the risk factors associated with CHD and construct a CHD risk prediction model for the prevention and control of cardiovascular diseases.Although many CHD risk prediction models have been reported,limitations that affect the clinical applicability of the models remain.Recently,a new strategy of combining risk factors and susceptibility genes to construct a CHD risk assessment model has been proposed,but its role in improving the effectiveness of assessment remains controversial.This article summarizes the progress of research in CHD risk assessment models,analyzes the limitations of risk assessment models,and explores the new strategies of combining new risk factors with susceptibility genes to improve the effectiveness of CHD assessment.
作者
吴孟娜
年士艳
叶丹
张春婷
冯磊
WU Mengna;NIAN Shiyan;YE Dan;ZHANG Chunting;FENG Lei(Department of Laboratory,The Sixth Affiliated Hospital of Kunming Medical University,Yuxi,Yunnan,China,653100;Intensive Care Unit,The Sixth Affiliated Hospital of Kunming Medical University,Yuxi,Yunnan,China,653100)
出处
《分子诊断与治疗杂志》
2020年第7期839-842,847,F0002,共6页
Journal of Molecular Diagnostics and Therapy
基金
国家自然科学基金(81460326)
云南省科技厅—昆明医科大学应用基础研究联合专项[2018FE001(-081)]
云南省教育厅科学研究基金(2020Y0140)。
关键词
冠心病
风险评估模型
危险因子
易感基因
Coronary heart disease
Risk assessment model
Risk factor
Susceptibility gene
