摘要
骨髓微环境尤其是间充质干细胞(MSC)、成骨细胞等的相关转变,会导致白血病的发生。骨形态发生蛋白作为已知唯一能够诱导MSC向成骨细胞分化的形态发生因子,在骨髓微环境调控白血病发生、发展中的作用日益得到重视。急性髓细胞来源的MSC会通过骨形态发生蛋白诱导K562-ADM细胞的形态转化和耐药。文章综述了骨形态发生蛋白(BMP)的相关研究,以期能够为白血病的治疗提供新的靶点与方向。
The related changes of bone marrow microenvironment(especially mesenchymal stem cells and osteoblasts)would lead to the occurrence of leukemia.Bone morphogenetic protein(BMP)is considered to be the only known morphogenetic factor capable of inducing differentiation of mesenchymal stem cells into osteoblasts,and its role in regulating the occurrence and development of leukemia in the bone marrow microenvironment has been paid more attention.The studies found that acute myeloid leukemia derived-mesenchymal stem cells induced the morphologic transformation and resistance of K562-ADM through BMP.This paper reviews the related research of BMP in order to provide new targets and directions for the research and treatment of leukemia.
作者
李海鹰
戴福宏
Li Haiying;Dai Fuhong(Department of Internal Medicine,School of Clinical Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China)
出处
《白血病．淋巴瘤》
CAS
2020年第6期378-381,共4页
Journal of Leukemia & Lymphoma
