摘要
目的探讨芪苈强心胶囊联合辅酶Q10治疗慢性心力衰竭(CHF)的临床效果。方法选取CHF患者184例,随机分为对照组和观察组,每组92例。常规治疗基础上,对照组采用辅酶Q10治疗,观察组在对照组基础上采用芪苈强心胶囊治疗。比较两组的疗效、治疗前、治疗1个月后超声心动图指标[左室射血分数(LVEF)、每搏量(SV)、左心室舒张末期内径(LVEDD)]、和肽素(Copeptin)、半乳糖凝集素-3(Gal-3)水平。结果观察组的治疗总有效率、LVEF和SV均显著高于对照组,LVEDD、Copeptin和Gal-3水平则低于对照组(P<0.05或0.01)。结论芪苈强心胶囊联合辅酶Q10治疗CHF疗效显著,可改善Copeptin和Gal-3水平,改善患者的心功能。
Objective To investigate the clinical effect of Qili Qiangxin Capsule combined with Coenzyme Q10 in the treatment of chronic heart failure(CHF).Methods A total of 184 patients with CHF were selected and randomly divided into the Control Group and the Observation Group,92 cases in each group.On the basis of conventional treatment,the Control Group was treated with coenzyme Q10 while the Observation Group was treated with Qili Qiangxin Capsule.The two groups were compared in terms of the efficacy,echocardiographic indicators[left ventricular ejection fraction(LVEF),stroke volume(SV),and left ventricular end-diastolic diameter(LVEDD)],copeptin,and galectin-3(Gal-3)levels before the treatment and 1 month after the treatment.Results The Observation Group had the total effective rate,LVEF and SV significantly higher than the Control Group(P<0.05),but had the LVEDD,copeptin and Gal-3 levels significantly lower than the Control Group(P<0.01).Conclusion Qili Qiangxin Capsule combined with coenzyme Q10 has a significant effect in the treatment of CHF,and can improve the levels of copeptin and Gal-3 and improve cardiac function of patients.
作者
李善敬
许锦荣
陈庞何
郭英杰
吕冬
苏成标
唐燕平
LI Shan-jing;XU Jin-rong;CHEN Pang-he;GUO Ying-jie;LV Dong;SU Cheng-biao;TANG Yan-ping(Department of Emergency,the Second Affiliated Hospital of Guangdong Medical University,Zhanjiang 524003,China;Department of Cardiovascular Medicine,the Second Affiliated Hospital of Guangdong Medical University,Zhanjiang 524003,China)
出处
《广东医科大学学报》
2020年第4期407-409,共3页
Journal of Guangdong Medical University
基金
湛江市财政资金科技专项竞争性分配项目(No.2017A01029)。
