摘要
目的观察青宝散外敷治疗非哺乳期乳腺炎的临床疗效。方法将60例非哺乳期乳腺炎患者按照随机数字表法分为2组。对照组30例予清热解毒散结方口服治疗;治疗组30例在对照组治疗基础上予青宝散外敷。2组均治疗30 d。比较2组治疗前后免疫指标CD8^+、CD20^+、CD68^+及炎症指标白细胞介素1β(IL-1β)、IL-2、IL-6水平,各症状、体征评分及总分变化,并统计疗效。结果治疗组总有效率90%(27/30),对照组总有效率60%(18/30),治疗组疗效优于对照组(P <0. 05)。治疗组治疗14 d和30 d后,各项症状、体征评分及总分均较本组治疗前降低(P <0. 05);对照组治疗14 d后创周肤色、疼痛程度及总分均较本组治疗前降低(P <0. 05),治疗30 d后各项症状、体征评分均较本组治疗前降低(P <0. 05)。2组治疗30 d后各项症状、体征评分及总分均低于本组治疗14 d(P <0. 05)。治疗组治疗14 d后肿块形态、创周肤色、疼痛程度及总分均低于对照组同期(P <0. 05),治疗30 d后各项症状、体征评分及总分均低于对照组同期(P <0. 05)。治疗后2组CD8^+水平均较本组治疗前升高(P <0. 05),CD20^+、CD68^+水平均降低(P <0. 05);治疗组治疗后CD8^+水平高于对照组(P <0. 05),CD20^+、CD68^+水平低于对照组(P <0. 05)。治疗后2组IL-1β、IL-2、IL-6水平均较本组治疗前降低(P <0. 05),且治疗后治疗组均低于对照组(P <0. 05)。结论青宝散外敷通过调节免疫紊乱,改善局部炎症反应,达到治疗非哺乳期乳腺炎的效果,疗效显著,安全性高。
Objective To observe the effect of external application of Qingbao powder on non lactation mastitis. Methods 60 patients with non lactation mastitis were randomly divided into two groups according to the random number table method. 30 cases in the control group were treated by Qingre Jiedu Sanjie decoction. 30 cases in the treatment group were treated by Qingbao powder on the basis of the control group. Both groups were treated for 30 days. The levels of immune indexes CD8^+,CD20^+,CD68^+ and inflammatory indexes such as interleukin 1β( IL-1β),IL-2 and IL-6 were compared between the two groups before and after treatment. The score of symptoms,signs and total scores were compared between the two groups before and after treatment,and the clinical efficacy of the two groups was counted. Results The total effective rate of the treatment group was 90%( 27/30),and that of the control group was 60%( 18/30). The curative effect of the treatment group was better than that of the control group( P < 0. 05). After 14 days and 30 days of treatment,the scores of symptoms,signs and total scores in the treatment group were lower than those before treatment( P < 0. 05). After 14 days of treatment,the skin color,pain degree and total score of the control group were lower than those before treatment( P < 0. 05),and the scores of symptoms and signs after 30 days of treatment were lower than those before treatment in this group( P < 0. 05). After30 days of treatment,the scores of the two groups were lower than those of the group after 14 days of treatment( P <0. 05). After 14 days of treatment,the shape of tumor,skin color around the wound,pain degree and total score of the treatment group were lower than those of the control group at the same period( P < 0. 05). The scores of symptoms,signs and total scores after 30 days of treatment in the treatment group were lower than those in the same period of the control group( P < 0. 05). After treatment,the levels of CD8^+in the two groups were higher than those in the group before treatment( P < 0. 05),the levels of CD20^+and CD68^+were decreased( P < 0. 05). After treatment,the level of CD8^+in the treatment group was higher than that in the control group( P < 0. 05),and the levels of CD20^+and CD68^+in the treatment group were lower than those in the control group( P < 0. 05). After treatment,the levels of IL-1β,IL-2 and IL-6 in the two groups were lower than those in the group before treatment( P < 0. 05),and those in the treatment group were lower than those in the control group( P < 0. 05). Conclusion Qingbao powder can achieve the effect of treating non lactation mastitis by regulating immune disorder and improving local inflammatory reaction. It has significant clinical application effect and high safety.
作者
唐甜
张军
张卫东
王敦英
TANG Tian;ZHANG Jun;ZHANG Weidong(Department of Thyroid and Breast Surgery,Wuxi Hospital of Traditional Chinese Medicine,Nanjing University of Traditional Chinese Medicine,Wuxi,Jiangsu 214071)
出处
《河北中医》
2020年第4期517-521,共5页
Hebei Journal of Traditional Chinese Medicine
基金
无锡市卫生计生委2018年度科研项目(编号:MS201841)。
关键词
乳腺炎
中药疗法
中药外敷
Mastitis
Chinese medicine therapy
External application of Chinese medicine
