摘要
目的探讨清中汤辅助治疗幽门螺杆菌(Hp)相关性胃溃疡的效果。方法将116例Hp相关性胃溃疡患者随机分为两组各58例,对照组接受常规西医治疗,研究组在其基础上加用清中汤治疗。治疗前后对患者的主要症状进行积分,检测胃泌素(GAS)、胃动素(MTL)、胆囊收缩素(CCK)水平,判断临床疗效和Hp根除情况。结果两组治疗后的上腹痛、反酸、腹胀等主要症状积分均显著下降(P <0.05),而研究组显著低于对照组(P <0.05)。两组治疗后的血清CCK、GAS水平均显著下降(P <0.05),MTL水平显著升高(P <0.05),而研究组CCK、GAS水平显著低于对照组(P <0.05),MTL水平显著高于对照组(P <0.05)。研究组治愈率为43.10%,有效率为53.45%,无效率为3.45%,Hp根除率为56.90%;对照组治愈率为24.14%,有效率为56.90%,无效率为18.97%,Hp根除率为34.48%,研究组的临床疗效和Hp根除率明显优于对照组(P <0.05)。结论清中汤治疗相关性胃溃疡,能够有效缓解症状,改善胃泌素指标,提升疗效,并且提高Hp根除率。
Objective To explore the curative effect of qingzhong decoction on helicobacter pylori associated gastric ulcer. Methods 158 patients with helicobacter pylori associated gastric ulcer were randomly divided into two groups,58 patients in each group.The control group were treated with conventional western medicine treatment, and the study group were treated with qingzhongdecoction.The main symptoms of the patients were scored before and after treatment, and the levels of gastrin(GAS), motilin(MTL) and cholecystokinin(CCK) were detected to judge the clinical efficacy and Hperadication. Results After treatment, the scores of major symptoms such as epigastric pain, acid reflux, burning sensation and abdominal distension in both groups were significantly decreased(P<0.05), while those in the study group were significantly lower than those in the control group(P<0.05).After treatment, serum CCK and GAS levels in both groups were significantly decreased(P<0.05), and MTL levels were significantly increased(P<0.05), while CCK and GAS levels in the study group were significantly lower than those in the control group(P<0.05), and MTL levels were significantly higher than those in the control group(P<0.05). The cure rate, effective rate, ineffective rate and Hp eradication rate in the study group were 43.10%, 53.45%, 3.45% and 56.90% respectively, while in the control group was 24.14%, 56.90%, 18.97%, 34.48%. The clinical efficacy and Hp eradication rate of the study group were significantly better than the control group(P<0.05). Conclusion Qingzhong decoction in the treatment of related gastric ulcer can effectively alleviate symptoms, improve gastrin indicators, improve curative effect, and improve the eradication rate of Hp.
作者
赫珈
HE Jia(No.3 Department of Internal Medicine,Fengcheng Hospital of Traditional Chinese Medicine,Dandong 118100,China)
出处
《中国医药指南》
2020年第21期179-180,共2页
Guide of China Medicine
关键词
清中汤
幽门螺杆菌
胃溃疡
Clear soup
Helicobacter pylori
Gastric ulcer
